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Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion
Alternative TitleClinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion
Zhao Jing; Luo XiangDong; Da ChunLi; Xin Yan
2009
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume15Issue:17Pages:2145-2150
AbstractAIM: To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC).
Other AbstractAIM: To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) expression and the clinicopathological features of gastric carcinoma (GC). METHODS: Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2+/ki-67- cells in 162 cases of GC and its matched normal mucosa and precancerous lesion. RESULTS: The positive rate of Bmi-1 expression in GC (52.5%) was significantly higher than that in normal gastric mucosa (21.6%, χ~ 2= 33.088, P < 0.05). The Bmi-1 expression in GC was closely related with the Lauren's and Borrmann's classification and clinical stage (χ~2 = 4.400, 6.122 and 11.190, respectively, P < 0.05). The expression of ki-67 was related to the Borrmann's classification (χ~2 = 13.380, P < 0.05). Bcl-2 expression was correlated with the Lauren's classification (χ~2 = 4.725, P < 0.05), and the Bmi-1 expression both in GC ( rk = 0.157, P < 0.05) and in intestinal metaplasia ( rk = 0.270, P < 0.05). CONCLUSION: Abnormal Bmi-1 expression in GC may be involved in cell proliferation, apoptosis and cancerization. This marker can objectively indicate the clinicopathological characteristics of GC.
KeywordSTEM-CELLS GASTROINTESTINAL-TRACT BREAST-CANCER BMI-1 SENESCENCE PROGNOSIS TUMORIGENESIS ONCOGENE PROTEIN B-cell-specific Moloney murine leukemia virus insertion site 1 Gastric carcinoma Precancerous lesion Cell proliferation Apoptosis
Indexed ByCSCD
Language英语
CSCD IDCSCD:3614410
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144372
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhao Jing,Luo XiangDong,Da ChunLi,et al. Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(17):2145-2150.
APA Zhao Jing,Luo XiangDong,Da ChunLi,&Xin Yan.(2009).Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion.WORLD JOURNAL OF GASTROENTEROLOGY,15(17),2145-2150.
MLA Zhao Jing,et al."Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion".WORLD JOURNAL OF GASTROENTEROLOGY 15.17(2009):2145-2150.
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