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Ureido-modification of the resin-bound LHRH analogue with N,N '-carbonyldiimidazole
Alternative TitleUreido-modification of the resin-bound LHRH analogue with N,N′-carbonyldiimidazole
Gao Yong Qing1; Zhou Ning1; Lv Yu Jian1; Cheng Mao Sheng2; Liu Ke Liang1
2009
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume20Issue:6Pages:668-671
AbstractThe ureido-modification of the resin-bound a luteinizing hormone releasing hormone (LHRH) analogue was investigated by CDI-activating method. The an-lino group at the side chain of LHRH analogue could be transformed into various substituted urea moieties in high yields. However, its terminal amino group was partially converted to a hydantoin structure due to the attack of the N atom of the adjacent amide bond. (C) 2009 Ke Liang Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractThe ureido-modification of the resin-bound a luteinizing hormone releasing hormone (LHRH) analogue was investigated by CDI-activating method. The amino group at the side chain of LHRH analogue could be transformed into various substituted urea moieties in high yields. However, its terminal amino group was partially converted to a hydantoin structure due to the attack of the N atom of the adjacent amide bond.
KeywordUREAS Urea moiety N,N'-carbonyldiimidazole (CDI) Solid-phase Peptide
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:3757051
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144431
Collection中国科学院金属研究所
Affiliation1.Beijing Institute Pharmacol & Toxicol, Beijing 100850, Peoples R China
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Gao Yong Qing,Zhou Ning,Lv Yu Jian,et al. Ureido-modification of the resin-bound LHRH analogue with N,N '-carbonyldiimidazole[J]. CHINESE CHEMICAL LETTERS,2009,20(6):668-671.
APA Gao Yong Qing,Zhou Ning,Lv Yu Jian,Cheng Mao Sheng,&Liu Ke Liang.(2009).Ureido-modification of the resin-bound LHRH analogue with N,N '-carbonyldiimidazole.CHINESE CHEMICAL LETTERS,20(6),668-671.
MLA Gao Yong Qing,et al."Ureido-modification of the resin-bound LHRH analogue with N,N '-carbonyldiimidazole".CHINESE CHEMICAL LETTERS 20.6(2009):668-671.
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