| TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis | |
| Alternative Title | TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis |
| Wang BenGang; Yi DeHui; Liu YongFeng | |
| 2015 | |
| Source Publication | CHINESE JOURNAL OF CANCER
 |
| ISSN | 1000-467X |
| Volume | 34Issue:6 |
| Abstract | Introduction: Recent studies examining the association of Toll-like receptor 3 (TLR3) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk. |
| Other Abstract | Introduction Recent studies examining the association of Toll-like receptor 3 ( TLR3 ) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk. Methods We systematically reviewed studies that focused on a collection of 12 SNPs located in the TLR3 gene and the details by which these SNPs influenced cancer risk. Additionally, 14 case-control studies comprising a total of 7997 cases of cancer and 8699 controls were included in a meta-analysis of 4 highly studied SNPs (rs3775290, rs3775291, rs3775292, and rs5743312). Results The variant TLR3 genotype rs5743312 (C9948T, intron 3, C?>?T) was significantly associated with an increased cancer risk as compared with the wild-type allele (odds ratio OR?=?1.11, 95% confidence interval CI?=?1.00–1.24, P ?=?0.047). No such association was observed with other TLR3 SNPs. In the stratified analysis, the rs3775290 (C13766T, C?>?T) variant genotype was found to be significantly associated with an increased cancer risk in Asian populations. Additionally, the rs3775291 (G13909A, G?>?A) variant genotype was significantly associated with an increased cancer risk in Asians, subgroup with hospital-based controls, and subgroup with a small sample size. Conclusion After data integration, our findings suggest that the TLR3 rs5743312 polymorphism may contribute to an increased cancer risk. |
| Keyword | NORTH INDIAN POPULATION TOLL-LIKE RECEPTORS BREAST-CANCER NASOPHARYNGEAL CARCINOMA RISK ASSOCIATION SUSCEPTIBILITY DISEASE HUMANS BIAS The Toll-like receptor 3 (TLR3) gene Single nucleotide polymorphism Cancer risk Meta-analysis Systematic review |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:5454251 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/144535 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Wang BenGang,Yi DeHui,Liu YongFeng. TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis[J]. CHINESE JOURNAL OF CANCER,2015,34(6). |
| APA | Wang BenGang,Yi DeHui,&Liu YongFeng.(2015).TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis.CHINESE JOURNAL OF CANCER,34(6). |
| MLA | Wang BenGang,et al."TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis".CHINESE JOURNAL OF CANCER 34.6(2015). |
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