TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

IMR OpenIR

	TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis
其他题名	TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis
	Wang BenGang; Yi DeHui; Liu YongFeng
	2015
发表期刊	CHINESE JOURNAL OF CANCER
ISSN	1000-467X
卷号	34 期号:6
摘要	Introduction: Recent studies examining the association of Toll-like receptor 3 (TLR3) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk.
其他摘要	Introduction Recent studies examining the association of Toll-like receptor 3 ( TLR3 ) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk. Methods We systematically reviewed studies that focused on a collection of 12 SNPs located in the TLR3 gene and the details by which these SNPs influenced cancer risk. Additionally, 14 case-control studies comprising a total of 7997 cases of cancer and 8699 controls were included in a meta-analysis of 4 highly studied SNPs (rs3775290, rs3775291, rs3775292, and rs5743312). Results The variant TLR3 genotype rs5743312 (C9948T, intron 3, C?>?T) was significantly associated with an increased cancer risk as compared with the wild-type allele (odds ratio OR?=?1.11, 95% confidence interval CI?=?1.00–1.24, P ?=?0.047). No such association was observed with other TLR3 SNPs. In the stratified analysis, the rs3775290 (C13766T, C?>?T) variant genotype was found to be significantly associated with an increased cancer risk in Asian populations. Additionally, the rs3775291 (G13909A, G?>?A) variant genotype was significantly associated with an increased cancer risk in Asians, subgroup with hospital-based controls, and subgroup with a small sample size. Conclusion After data integration, our findings suggest that the TLR3 rs5743312 polymorphism may contribute to an increased cancer risk.
关键词	NORTH INDIAN POPULATION TOLL-LIKE RECEPTORS BREAST-CANCER NASOPHARYNGEAL CARCINOMA RISK ASSOCIATION SUSCEPTIBILITY DISEASE HUMANS BIAS The Toll-like receptor 3 (TLR3) gene Single nucleotide polymorphism Cancer risk Meta-analysis Systematic review
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:5454251
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144535
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Wang BenGang,Yi DeHui,Liu YongFeng. TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis[J]. CHINESE JOURNAL OF CANCER,2015,34(6).
APA	Wang BenGang,Yi DeHui,&Liu YongFeng.(2015).TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis.CHINESE JOURNAL OF CANCER,34(6).
MLA	Wang BenGang,et al."TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis".CHINESE JOURNAL OF CANCER 34.6(2015).