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TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis
Alternative TitleTLR3 gene polymorphisms in cancer: a systematic review and meta-analysis
Wang BenGang; Yi DeHui; Liu YongFeng
2015
Source PublicationCHINESE JOURNAL OF CANCER
ISSN1000-467X
Volume34Issue:6
AbstractIntroduction: Recent studies examining the association of Toll-like receptor 3 (TLR3) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk.
Other AbstractIntroduction Recent studies examining the association of Toll-like receptor 3 ( TLR3 ) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on cancer risk. Methods We systematically reviewed studies that focused on a collection of 12 SNPs located in the TLR3 gene and the details by which these SNPs influenced cancer risk. Additionally, 14 case-control studies comprising a total of 7997 cases of cancer and 8699 controls were included in a meta-analysis of 4 highly studied SNPs (rs3775290, rs3775291, rs3775292, and rs5743312). Results The variant TLR3 genotype rs5743312 (C9948T, intron 3, C?>?T) was significantly associated with an increased cancer risk as compared with the wild-type allele (odds ratio OR?=?1.11, 95% confidence interval CI?=?1.00–1.24, P ?=?0.047). No such association was observed with other TLR3 SNPs. In the stratified analysis, the rs3775290 (C13766T, C?>?T) variant genotype was found to be significantly associated with an increased cancer risk in Asian populations. Additionally, the rs3775291 (G13909A, G?>?A) variant genotype was significantly associated with an increased cancer risk in Asians, subgroup with hospital-based controls, and subgroup with a small sample size. Conclusion After data integration, our findings suggest that the TLR3 rs5743312 polymorphism may contribute to an increased cancer risk.
KeywordNORTH INDIAN POPULATION TOLL-LIKE RECEPTORS BREAST-CANCER NASOPHARYNGEAL CARCINOMA RISK ASSOCIATION SUSCEPTIBILITY DISEASE HUMANS BIAS The Toll-like receptor 3 (TLR3) gene Single nucleotide polymorphism Cancer risk Meta-analysis Systematic review
Indexed ByCSCD
Language英语
CSCD IDCSCD:5454251
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144535
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Wang BenGang,Yi DeHui,Liu YongFeng. TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis[J]. CHINESE JOURNAL OF CANCER,2015,34(6).
APA Wang BenGang,Yi DeHui,&Liu YongFeng.(2015).TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis.CHINESE JOURNAL OF CANCER,34(6).
MLA Wang BenGang,et al."TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis".CHINESE JOURNAL OF CANCER 34.6(2015).
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