| Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment | |
| Alternative Title | Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment |
| Xu Tianhua; Sheng Zitong; Yao Li | |
| 2017 | |
| Source Publication | FRONTIERS OF MEDICINE
 |
| ISSN | 2095-0217 |
| Volume | 11Issue:3Pages:340-348 |
| Abstract | In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (< 3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin-angiotensin-aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG. |
| Other Abstract | In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria ( <3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG. |
| Keyword | RENAL INJURY WEIGHT-LOSS LIPID-ACCUMULATION INSULIN-RESISTANCE BARIATRIC SURGERY KIDNEY REDUCTION LEPTIN DIET HYPERFILTRATION obesity-related glomerulopathy pathogenesis pathologic clinical characteristics |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:6114021 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/144828 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Xu Tianhua,Sheng Zitong,Yao Li. Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment[J]. FRONTIERS OF MEDICINE,2017,11(3):340-348. |
| APA | Xu Tianhua,Sheng Zitong,&Yao Li.(2017).Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment.FRONTIERS OF MEDICINE,11(3),340-348. |
| MLA | Xu Tianhua,et al."Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment".FRONTIERS OF MEDICINE 11.3(2017):340-348. |
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