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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
Alternative TitleObesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
Xu Tianhua; Sheng Zitong; Yao Li
2017
Source PublicationFRONTIERS OF MEDICINE
ISSN2095-0217
Volume11Issue:3Pages:340-348
AbstractIn light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (< 3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin-angiotensin-aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
Other AbstractIn light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria ( <3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
KeywordRENAL INJURY WEIGHT-LOSS LIPID-ACCUMULATION INSULIN-RESISTANCE BARIATRIC SURGERY KIDNEY REDUCTION LEPTIN DIET HYPERFILTRATION obesity-related glomerulopathy pathogenesis pathologic clinical characteristics
Indexed ByCSCD
Language英语
CSCD IDCSCD:6114021
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144828
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Xu Tianhua,Sheng Zitong,Yao Li. Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment[J]. FRONTIERS OF MEDICINE,2017,11(3):340-348.
APA Xu Tianhua,Sheng Zitong,&Yao Li.(2017).Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment.FRONTIERS OF MEDICINE,11(3),340-348.
MLA Xu Tianhua,et al."Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment".FRONTIERS OF MEDICINE 11.3(2017):340-348.
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