Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

IMR OpenIR

	Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
其他题名	Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
	Xu Tianhua; Sheng Zitong; Yao Li
	2017
发表期刊	FRONTIERS OF MEDICINE
ISSN	2095-0217
卷号	11 期号:3 页码:340-348
摘要	In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (< 3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin-angiotensin-aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
其他摘要	In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria ( <3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
关键词	RENAL INJURY WEIGHT-LOSS LIPID-ACCUMULATION INSULIN-RESISTANCE BARIATRIC SURGERY KIDNEY REDUCTION LEPTIN DIET HYPERFILTRATION obesity-related glomerulopathy pathogenesis pathologic clinical characteristics
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:6114021
引用统计	被引频次：4[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144828
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Xu Tianhua,Sheng Zitong,Yao Li. Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment[J]. FRONTIERS OF MEDICINE,2017,11(3):340-348.
APA	Xu Tianhua,Sheng Zitong,&Yao Li.(2017).Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment.FRONTIERS OF MEDICINE,11(3),340-348.
MLA	Xu Tianhua,et al."Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment".FRONTIERS OF MEDICINE 11.3(2017):340-348.