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Chondroitinase ABC improves recovery of long sciatic nerve defects
Alternative TitleChondroitinase ABC improves recovery of long sciatic nerve defects ☆
Yu Hailong1; Xiang Liangbi1; Xu Wenjing2; Zhao Bin2; Wang Yu2; Peng Jiang2; Lu Shibi2
2012
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume7Issue:1Pages:61-65
AbstractSciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting.
Other AbstractSciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting.
KeywordGROWTH-FACTOR SULFATE PROTEOGLYCAN CHEMICAL-EXTRACTION LOCAL RELEASE REGENERATION GRAFTS REPAIR RAT chondroitinase ABC neural regeneration peripheral nerve sciatic nerve Schwann cell
Indexed ByCSCD
Language英语
Funding Project[Liaoning Scientific Research Foundation of Doctor] ; [Beijing Natural Science Foundation]
CSCD IDCSCD:4439030
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/144911
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Chinese PLA, Institute Orthoped, Gen Hosp, Beijing 100853, Peoples R China Institute Orthoped Gen Hosp
Recommended Citation
GB/T 7714
Yu Hailong,Xiang Liangbi,Xu Wenjing,et al. Chondroitinase ABC improves recovery of long sciatic nerve defects[J]. NEURAL REGENERATION RESEARCH,2012,7(1):61-65.
APA Yu Hailong.,Xiang Liangbi.,Xu Wenjing.,Zhao Bin.,Wang Yu.,...&Lu Shibi.(2012).Chondroitinase ABC improves recovery of long sciatic nerve defects.NEURAL REGENERATION RESEARCH,7(1),61-65.
MLA Yu Hailong,et al."Chondroitinase ABC improves recovery of long sciatic nerve defects".NEURAL REGENERATION RESEARCH 7.1(2012):61-65.
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