Chondroitinase ABC improves recovery of long sciatic nerve defects

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	Chondroitinase ABC improves recovery of long sciatic nerve defects
其他题名	Chondroitinase ABC improves recovery of long sciatic nerve defects ☆
	Yu Hailong 1; Xiang Liangbi 1; Xu Wenjing 2; Zhao Bin 2; Wang Yu 2; Peng Jiang 2; Lu Shibi 2
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:1 页码:61-65
摘要	Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting.
其他摘要	Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting.
关键词	GROWTH-FACTOR SULFATE PROTEOGLYCAN CHEMICAL-EXTRACTION LOCAL RELEASE REGENERATION GRAFTS REPAIR RAT chondroitinase ABC neural regeneration peripheral nerve sciatic nerve Schwann cell
收录类别	CSCD
语种	英语
资助项目	[Liaoning Scientific Research Foundation of Doctor] ; [Beijing Natural Science Foundation]
CSCD记录号	CSCD:4439030
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/144911
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Chinese PLA, Institute Orthoped, Gen Hosp, Beijing 100853, Peoples R China Institute Orthoped Gen Hosp
推荐引用方式 GB/T 7714	Yu Hailong,Xiang Liangbi,Xu Wenjing,et al. Chondroitinase ABC improves recovery of long sciatic nerve defects[J]. NEURAL REGENERATION RESEARCH,2012,7(1):61-65.
APA	Yu Hailong.,Xiang Liangbi.,Xu Wenjing.,Zhao Bin.,Wang Yu.,...&Lu Shibi.(2012).Chondroitinase ABC improves recovery of long sciatic nerve defects.NEURAL REGENERATION RESEARCH,7(1),61-65.
MLA	Yu Hailong,et al."Chondroitinase ABC improves recovery of long sciatic nerve defects".NEURAL REGENERATION RESEARCH 7.1(2012):61-65.