| Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study | |
| Alternative Title | Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study |
| Li Huichun1; Zhang Mingyuan2; Wang Gang3; Zhang Honggeng4; Zhang Hongyan5; Liu Ying6; Li Ming7; Zhang Congpei8; Tang Jisheng9; Wu Wenyuan10; Singh Pritibha11; Granger Renee Elizabeth11; Raskin Joel12; Ang Qiuqing13 | |
| 2010 | |
| Source Publication | CHINESE MEDICAL JOURNAL
 |
| ISSN | 0366-6999 |
| Volume | 123Issue:15Pages:2063-2069 |
| Abstract | Background Painful physical symptoms (PPS) may present as a component of major depressive disorder (MDD). Their effect in Chinese patients has not been investigated. This analysis reports the changes in disease severity, treatment patterns, quality of life and outcomes in a Chinese cohort according to the presence (PPS+) or absence (PPS-) of painful physical symptoms. |
| Other Abstract | Background Painful physical symptoms (PPS) may present as a component of major depressive disorder (MDD). Their effect in Chinese patients has not been investigated. This analysis reports the changes in disease severity, treatment patterns, quality of life and outcomes in a Chinese cohort according to the presence (PPS+) or absence (PPS-) of painful physical symptoms. Methods A subgroup of Chinese patients from a large observational 3-month study of patients from Asian countries and regions of China were classified using the modified Somatic Symptom Inventory (SSI) as PPS+ (mean score ≥2) or PPS(mean score <2). Depression severity was assessed with the Clinical Global Impression of Severity (CGI-S) scale and 17-item Hamilton depression rating scale (HAMD17). Pain severity was measured using a visual analogue scale (VAS), while the Euro QoL (EQ-5D) assessed patient well-being. Antidepressants were compared with regard to their efficacy. Results Of the 299 Chinese patients enrolled in the study, 105 were classified as PPS+ (73/105, 70% women). At baseline, PPS+ patients reported greater pain severity (VAS, mean (SD): 49.56 (26.49) vs. 16.60 (20.99) for PPS-, P <0.01), were more depressed (HAMD17, mean (SD): 25.32 (5.47) vs. 23.33 (5.24) for PPS-, P=0.002) and had poorer quality of life (EQ-5D Health State, mean (SD): 38.48 (22.38) vs. 49.57 (18.54) for PPS-, P <0.001). PPS+ patients showed less overall improvement in depressive symptom severity (HAMD_(17), change from baseline (95% Cl): -17.38 (-18.65, -16.12) vs. -19.20 (-20.05, -18.35) for PPS-, P=0.032; CGI-S, change from baseline (95% Cl): -2.85 (-3.11, -2.58) vs. -3.20 (-3.38, -3.02) for PPS-, P=0.044). Conclusions PPS were less frequent than expected compared with previous studies of Asian populations. PPS+ were associated with greater MDD severity and less improvement than PPS- when antidepressants were given |
| Keyword | QUALITY-OF-LIFE SOMATIC SYMPTOMS PRIMARY-CARE HEALTH-CARE SEVERITY AMERICA IMPACT ASIA depressive disorder major pain quality of life epidemiology public health China |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Eli Lilly and Company, Indianapolis, USA] |
| CSCD ID | CSCD:3966044 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/145079 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.浙江大学 2.Shanghai Institute Mental Hlth, Shanghai 200030, Peoples R China 3.An Ding Hosp, Beijing 100088, Peoples R China 4.Hunan Prov Hosp Brain Dis, Mental Hlth Ctr, Changsha 410007, Hunan, Peoples R China 5.Beijing University, Hosp 6, Beijing 100083, Peoples R China 6.中国科学院金属研究所 7.Suzhou Guang Ji Hosp, Suzhou 215008, Jiangsu, Peoples R China 8.Harbin First Spec Hosp, Harbin 150056, Heilongjiang, Peoples R China 9.Shandong Mental Hlth Ctr, Jinan 250014, Shandong, Peoples R China 10.同济大学 11.Eli Lilly Australia Pty Ltd, Intercontinental Informat Science, Macquarie Pk 2113, Australia 12.Eli Lilly Canada, Lilly Res Labs, Toronto, ON M1N 2E8, Canada 13.Eli Lilly Asia Inc, Shanghai 200021, Peoples R China |
| Recommended Citation GB/T 7714 | Li Huichun,Zhang Mingyuan,Wang Gang,et al. Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study[J]. CHINESE MEDICAL JOURNAL,2010,123(15):2063-2069. |
| APA | Li Huichun.,Zhang Mingyuan.,Wang Gang.,Zhang Honggeng.,Zhang Hongyan.,...&Ang Qiuqing.(2010).Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study.CHINESE MEDICAL JOURNAL,123(15),2063-2069. |
| MLA | Li Huichun,et al."Association between painful physical symptoms and clinical outcomes in Chinese patients with major depressive disorder: a three-month observational study".CHINESE MEDICAL JOURNAL 123.15(2010):2063-2069. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment