Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China

IMR OpenIR

	Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China
其他题名	Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China
	He Quanying 1; Feng Jing 1; Zhang Xilong 1; Liang Zongan 1; Huang Shaoguang 1; Kang Jian 1; Wang Guangfa 1; Zhang Liqiang 1; Ma Lijun 1; Wang Bei 1; Lin Qichang 1; Zhang Jingnong 1; Liu Huiguo 1; Luo Yuanming 1; Liu Jianhong 1; Wang Shi 1; Xiao Gaohui 1; Lu Gan 1; Zhang Jin 1; Feng Xuewei 1; Chen Baoyuan 1; Chinese Med Assoc 1
	2010
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	123 期号:1 页码:18-22
摘要	Background Epidemiologic studies have shown an independent and definite association between obstructive sleep apnea (OSA) and hypertension. This study aimed to define the association between daytime blood pressure and severity of OSA in Chinese population in mainland of China.
其他摘要	Background Epidemiologic studies have shown an independent and definite association between obstructive sleep apnea (OSA) and hypertension. This study aimed to define the association between daytime blood pressure and severity of OSA in Chinese population in mainland of China. Methods Twenty university hospital sleep centers in mainland of China were invited by the Chinese Medical Association (CMA) to participate in this epidemiologic study and 2297 consecutive patients (aged 18-85 years; 1981 males and 316 females) referred to these twenty sleep centers for evaluation of OSA between January 2004 and April 2006 were prospectively enrolled. Nocturnal polysomnography was performed in each patient, and disease severity was assessed based on the apnea-hypopnea index (AHI). These patients were classfied into four groups: non-apneic control (control, n=257) with AHI ≤5 episodes/hour; mild sleep apnea (mild, n=402) with AHI >5 and ≤15 episodes/hour; moderate sleep apnea (moderate, n=460) with AHI >15 and ≤30 episodes/hour and severe sleep apnea (severe, n=1178) with AHI >30 episodes/hour. Daytime blood pressure measurements were performed under standardized conditions in each patient at 10 a.m. in office on the day of referring to sleep centers for getting average value. All the patients were requested to quit medications related to blood pressure for three days before the day of assessing.Results Both daytime systolic blood pressure and diastolic blood pressure values were significantly related to AHI positively (r = 0.201 and 0.276, respectively; both P values <0.001) and to nadir nocturnal oxygen saturation negatively (r= -0.215 and -0.277, respectively; both Pvalues <0.001), which were the parameters of OSA severity. In two special designed mean plots, means of daytime systolic and diastolic blood pressure increased gradually with increasing AHI. Beyond AHI of 61-65, this increasing trend reached a plateau.Conclusions The results showed that OSA severity was associated with daytime blood pressure until AHI of 61-65, providing evidence for early OSA management, especially in OSA patients with concomitant hypertension.
关键词	POSITIVE AIRWAY PRESSURE INTERMITTENT HYPOXIA HONG-KONG PREVALENCE HYPERTENSION ASSOCIATION MEN COMMUNITY WOMEN RESISTANT obstructive sleep apnea hypertension epidemiology blood pressure polysomnography
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:3817202
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/145324
专题	中国科学院金属研究所
作者单位	1.Beijing University Peoples Hosp 2.天津医科大学 3.南京医科大学 4.四川大学 5.上海交通大学 6.中国医科大学 7.北京大学 8.Henan Prov Peoples Hosp 9.山西医科大学 10.福建医科大学 11.马来西亚理科大学 12.广州医科大学 13.Guangxi Zhuang Autonomous Reg Peoples Hosp 14.中国科学院金属研究所 15.Beijing Gongan Hosp 16.Jiangsu Senil Hosp 17.宁夏医科大学
推荐引用方式 GB/T 7714	He Quanying,Feng Jing,Zhang Xilong,et al. Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China[J]. CHINESE MEDICAL JOURNAL,2010,123(1):18-22.
APA	He Quanying.,Feng Jing.,Zhang Xilong.,Liang Zongan.,Huang Shaoguang.,...&Chinese Med Assoc.(2010).Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China.CHINESE MEDICAL JOURNAL,123(1),18-22.
MLA	He Quanying,et al."Relationship of daytime blood pressure and severity of obstructive sleep apnea among Chinese: a multi-center investigation in China".CHINESE MEDICAL JOURNAL 123.1(2010):18-22.