The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats

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	The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats
其他题名	The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats
	Yang HaiBo; Xu ZhaoFa; Liu Wei; Deng Yu; Xu Bin
	2011
发表期刊	BIOMEDICAL AND ENVIRONMENTAL SCIENCES
ISSN	0895-3988
卷号	24 期号:5 页码:550-559
摘要	Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.
其他摘要	Objective This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride. Methods Rats were treated with either procyanidins or lycopene 2h before HgCI2 subcutaneously injection, once daily treatment for 2 successive days. Results In comparison with HgCI2 group, markers of renal function such as blood urea nitrogen in serum and urinary protein were decreased to(18.45±11.63) mmol/L and(15.93±9.36) mmol/L, (4.54±0.78) g/(g·Cr) and(4.40±1.12) g/(g·Cr). N-acetyl-beta-D-glucosaminidase, lactate dehydrogenase, alkaline phosphatase in urine were depressed to(125.49±11.68) U/(g·Cr), (103.73±21.79) U/(g·Cr), (101.99±12.28) U/(g·Cr), and(113.19±23.74) U/(g·Cr), (71.14±21.80) U/(g·Cr), (73.64±21.51) U/(g·Cr) in procyanidins and lycopene groups. Indicators of oxidative stress, for example, Glutathion was reduced to(45.58±9.89) μmol/(g·pro) and(45.33±5.90) μmol/(g·pro), and antioxidant enzymes such as superoxide dismutase, glutathione-peroxidase were enhanced to(43.07±10.97) U/(mg·pro) and(39.94±6.04) U/(mg·pro), (83.85±18.48) U/(mg·pro), and(85.62±12.68) U/(mg·pro). Malondialdehyde was lowered to(0.95±0.12) (μmol/g·pro) and(1.03±0.12) μmol/(g·pro) in procyanidins and lycopene groups. ROS generation was decreased by 27.63% and 16.40% and apoptosis was also decreased in procyanidins and lycopene groups respectively. Pathological changes were much better as well. Conclusion Procyanidins and Lycopene play some protective role against mercury kidney damage.
关键词	SEED PROANTHOCYANIDIN EXTRACT 90-DAY ORAL TOXICITY OXIDATIVE STRESS ASSAY MICE NEPHROTOXICITY CAROTENOIDS PREVENTION SELENIUM TISSUES Mercuric chloride Procyanidins Lycopene Renal damage Protection
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4347850
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/145791
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Yang HaiBo,Xu ZhaoFa,Liu Wei,et al. The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2011,24(5):550-559.
APA	Yang HaiBo,Xu ZhaoFa,Liu Wei,Deng Yu,&Xu Bin.(2011).The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,24(5),550-559.
MLA	Yang HaiBo,et al."The Protective Role of Procyanidins and Lycopene Against Mercuric Chloride Renal Damage in Rats".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 24.5(2011):550-559.