Early diagnosis of epithelial ovarian cancer with cDNA microarry

IMR OpenIR

	Early diagnosis of epithelial ovarian cancer with cDNA microarry
其他题名	Early diagnosis of epithelial ovarian cancer with cDNA microarry
	Chen Ying 1; Zheng Huachuan 2; Zhao Yujie 1; Xin Yan 1
	2008
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	20 期号:2 页码:110-114
摘要	Objective: To investigate the roles of tumor suppressor genes-PTEN, nm23H(1), VEGF(165), Tiam1, MMP-2, Timp2, HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC) and develop a novel method for the early diagnosis of EOC. Methods: We observed the different expression profiles of those genes in normal ovary(n=5) and ovarian cancer tissue (n=20) by cDNA microarray. Results: In EOC, PTEN, Timp2 and nm23H1 genes were down-regulated (CY-3/CY-50.5), compared with the normal ovary, whereas Tiam1, VEGF165, MMP- 2, HE4 and S100A4 genes were up-regulated (CY-3/CY-5>2.0). Among them, HE4 gene was remarkably elevated (CY-3/CY-5>5.0). Their expression was correlated with clinicopathological staging of EOC(P<0.01). Conclusion: Those genes are closely linked to the pathogenesis and progression of EOC. cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis.
其他摘要	Objective:To investigate the roles of tumor suppressor genes-PTEN,nm23H_1,VEGF_(165),Tiam1,MMP-2,Timp2,HE4 and S100A4 in tumorigenesis and progression of epithelial ovarian cancer(EOC)and develop a novel method for the early diagnosis of EOC.Methods:We observed the different expression profiles of those genes in normal ovary(n=5)and ovarian cancer tissue(n=20)by cDNA microarray.Results:In EOC,PTEN,Timp2 and nm23H_1 genes were down-regulated (CY-3/CY-5 2.0).Among them,HE4 gene was remarkably elevated(CY-3/CY-5>5.0).Their expression was correlated with clinicopathological staging of EOC(P<0.01).Conclusion:Those genes are closely linked to the pathogenesis and progression of EOC.cDNA microarray is an effective technique to screen molecular biological markers and predict the metastastic potential of EOC in early diagnosis.
关键词	TUMOR PROGRESSION CELLS genes cDNA microarray early diagnosis
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3299651
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/145846
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院地质与地球物理研究所
推荐引用方式 GB/T 7714	Chen Ying,Zheng Huachuan,Zhao Yujie,et al. Early diagnosis of epithelial ovarian cancer with cDNA microarry[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):110-114.
APA	Chen Ying,Zheng Huachuan,Zhao Yujie,&Xin Yan.(2008).Early diagnosis of epithelial ovarian cancer with cDNA microarry.CHINESE JOURNAL OF CANCER RESEARCH,20(2),110-114.
MLA	Chen Ying,et al."Early diagnosis of epithelial ovarian cancer with cDNA microarry".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):110-114.