Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives

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	Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives
其他题名	Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives
	Song Kaizhen; Ma Junjie; Wang Xiao; Gong Ping; Zhao Yanfang
	2014
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	30 期号:1 页码:75-81
摘要	A series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC50 values of 0.57, 0.45 and 1.45 mu mol/L, respectively.
其他摘要	A series of novel 2-hydrazinyl-4-morpholinothieno3,2-dpyrimidine derivatives was designed and synthesized. All of them were screened for their cytotoxic activities against large cell lung cancer(H460), colon cancer (HT-29) and adenocarcinomic lung cancer(A549) cell lines in vitro. The pharmacological results indicate that most of the target compounds show moderate to significant activities. Especially compound 17 exhibits the most potent antitumor activities against H460, HT-29 and A549 cell lines with IC_(50) values of 0.57, 0.45 and 1.45 μmol/L, respectively.
关键词	CANCER POTENT INHIBITOR KINASE 2-Hydrazinyl-4-morpholinothieno3,2-dpyrimidine Antitumor activity Cytotoxic activity
收录类别	CSCD
语种	英语
资助项目	[Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China]
CSCD记录号	CSCD:5051263
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146108
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Song Kaizhen,Ma Junjie,Wang Xiao,et al. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2014,30(1):75-81.
APA	Song Kaizhen,Ma Junjie,Wang Xiao,Gong Ping,&Zhao Yanfang.(2014).Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,30(1),75-81.
MLA	Song Kaizhen,et al."Synthesis and Antitumor Activities of Novel 4-Morpholinothieno3,2-dpyrimidine Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 30.1(2014):75-81.