| Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer | |
| Alternative Title | Clinical Significance of the Expression of Inducible Nitric Oxide Synthase in Non-Small Cell Lung Cancer |
| Yang Chunlu1; Wang Yong2; Zhao Jun1; Zhang Yiliang1 | |
| 2007 | |
| Source Publication | CHINESE JOURNAL OF CANCER RESEARCH
 |
| ISSN | 1000-9604 |
| Volume | 19Issue:2Pages:136-140 |
| Abstract | Objective: To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it's affection to the prognosis NSCLC patients. Methods: The expression of iNOS was detected in 50 NSCLC tissues by Immunohistochemistry technology. Results: There was positive expression in NSCLC ( positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis (P 0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P < 0.05). Conclusion: Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis. Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting tumor growth and metastasis. |
| Other Abstract | Objective: To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it's affection to the prognosis NSCLC patients. Methods: The expression of iNOS was detected in 50 NSCLC tissues by Immuno- histochemistry technology. Results: There was positive expression in NSCLC (positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis (P＜0.05). There was no significant difference between positive expression of iNOS and lung cancer histological types, TNM stages, T stages (P＞0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P＜0.05). Conclusion: Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis. Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting tumor growth and metastasis. |
| Keyword | ANGIOGENESIS APOPTOSIS HYPOXIA MICE NSCLC iNOS prognosis |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:2911742 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146173 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.Benxi Steel Co, Gen Hosp, Department Thorac Surg, Benxi 117000, Peoples R China |
| Recommended Citation GB/T 7714 | Yang Chunlu,Wang Yong,Zhao Jun,et al. Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(2):136-140. |
| APA | Yang Chunlu,Wang Yong,Zhao Jun,&Zhang Yiliang.(2007).Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer.CHINESE JOURNAL OF CANCER RESEARCH,19(2),136-140. |
| MLA | Yang Chunlu,et al."Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer".CHINESE JOURNAL OF CANCER RESEARCH 19.2(2007):136-140. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment