IMR OpenIR
Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer
Alternative TitleClinical Significance of the Expression of Inducible Nitric Oxide Synthase in Non-Small Cell Lung Cancer
Yang Chunlu1; Wang Yong2; Zhao Jun1; Zhang Yiliang1
2007
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume19Issue:2Pages:136-140
AbstractObjective: To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it's affection to the prognosis NSCLC patients. Methods: The expression of iNOS was detected in 50 NSCLC tissues by Immunohistochemistry technology. Results: There was positive expression in NSCLC ( positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis (P 0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P < 0.05). Conclusion: Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis. Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting tumor growth and metastasis.
Other AbstractObjective: To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it's affection to the prognosis NSCLC patients. Methods: The expression of iNOS was detected in 50 NSCLC tissues by Immuno- histochemistry technology. Results: There was positive expression in NSCLC (positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis (P<0.05). There was no significant difference between positive expression of iNOS and lung cancer histological types, TNM stages, T stages (P>0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P<0.05). Conclusion: Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis. Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting tumor growth and metastasis.
KeywordANGIOGENESIS APOPTOSIS HYPOXIA MICE NSCLC iNOS prognosis
Indexed ByCSCD
Language英语
CSCD IDCSCD:2911742
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/146173
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Benxi Steel Co, Gen Hosp, Department Thorac Surg, Benxi 117000, Peoples R China
Recommended Citation
GB/T 7714
Yang Chunlu,Wang Yong,Zhao Jun,et al. Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(2):136-140.
APA Yang Chunlu,Wang Yong,Zhao Jun,&Zhang Yiliang.(2007).Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer.CHINESE JOURNAL OF CANCER RESEARCH,19(2),136-140.
MLA Yang Chunlu,et al."Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer".CHINESE JOURNAL OF CANCER RESEARCH 19.2(2007):136-140.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang Chunlu]'s Articles
[Wang Yong]'s Articles
[Zhao Jun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang Chunlu]'s Articles
[Wang Yong]'s Articles
[Zhao Jun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang Chunlu]'s Articles
[Wang Yong]'s Articles
[Zhao Jun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.