Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer

IMR OpenIR

	Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer
其他题名	Clinical Significance of the Expression of Inducible Nitric Oxide Synthase in Non-Small Cell Lung Cancer
	Yang Chunlu 1; Wang Yong 2; Zhao Jun 1; Zhang Yiliang 1
	2007
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	19 期号:2 页码:136-140
摘要	Objective: To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it's affection to the prognosis NSCLC patients. Methods: The expression of iNOS was detected in 50 NSCLC tissues by Immunohistochemistry technology. Results: There was positive expression in NSCLC ( positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis (P 0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P < 0.05). Conclusion: Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis. Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting tumor growth and metastasis.
其他摘要	Objective: To study the expressive characteristics of iNOS in non-small cell lung carcinoma (NSCLC) and it's affection to the prognosis NSCLC patients. Methods: The expression of iNOS was detected in 50 NSCLC tissues by Immuno- histochemistry technology. Results: There was positive expression in NSCLC (positive rate 38.00%). The expression of iNOS had a correlation with lymph node metastasis (P＜0.05). There was no significant difference between positive expression of iNOS and lung cancer histological types, TNM stages, T stages (P＞0.05). But the data suggested that there was a direct correlation between expression of iNOS and clinical prognosis (P＜0.05). Conclusion: Positive expression of iNOS was observed in NSCLC, which correlated with postoperative survival time and lymph node metastasis. Although iNOS level had no significant relation with T stage, we find the positive rate in T2 stage was much higher than that in T1 stage. The result suggested that positive expression of iNOS was related to bad clinical prognosis because of promoting tumor growth and metastasis.
关键词	ANGIOGENESIS APOPTOSIS HYPOXIA MICE NSCLC iNOS prognosis
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:2911742
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146173
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Benxi Steel Co, Gen Hosp, Department Thorac Surg, Benxi 117000, Peoples R China
推荐引用方式 GB/T 7714	Yang Chunlu,Wang Yong,Zhao Jun,et al. Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(2):136-140.
APA	Yang Chunlu,Wang Yong,Zhao Jun,&Zhang Yiliang.(2007).Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer.CHINESE JOURNAL OF CANCER RESEARCH,19(2),136-140.
MLA	Yang Chunlu,et al."Clinical significance of the expression of inducible nitric oxide synthase in non-small cell lung cancer".CHINESE JOURNAL OF CANCER RESEARCH 19.2(2007):136-140.