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Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin
Alternative TitleSphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin
Zhang ZhenHai1; Wu ShuoDong2; Wang Bing3; Su Yang2; Jin JunZhe2; Kong Jing2; Wang HaoLin2
2008
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume14Issue:25Pages:4077-4081
AbstractAIM: To detect whether patients with a T tube after cholecystectomy and choledochotomy have duodenal-biliary reflux by measuring the radioactivity of Tc99m-labeled diethylene triamine penta-acetic acid (DTPA) in the bile and whether the patients with duodenal-biliary reflux have sphincter of Oddi hypomotility, by measuring the level of plasma and serum gastrin of the patients. Finally to if there is close relationship among sphincter of Oddi hypornotility, duodenal-biliary reflux and gastrointestinal peptides.
Other AbstractAIM: To detect whether patients with a T tube after cholecystectomy and choledochotomy have duodenalbiliary reflux by measuring the radioactivity of Tc99m-labeled diethylene triamine penta-acetic acid (DTPA) in the bile and whether the patients with duodenal-biliary reflux have sphincter of Oddi hypomotility, by measuring the level of plasma and serum gastrin of the patients. Finally to if there is close relationship among sphincter of Oddi hypomotility, duodenal-biliary reflux and gastrointestinal peptides.METHODS: Forty-five patients with a T tube after cholecystectomy and choledochotomy were divided into reflux group and control group. The level of plasma and serum gastrin of the patients and of 12 healthy volunteers were measured by radioimmunoassay. Thirty-four were selected randomly to undergo choledochoscope manometry. Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duration of contractions (SOD), duodenal pressure (DP) and common bile duct pressure (CBDP) were scored and analyzed.RESULTS: Sixteen (35.6%) patients were detected to have duodenal-biliary reflux. SOBP, SOCA and CBDP in the reflux group were much lower than the control group (t=5.254, 3.438 and 3.527, P<0.001). SOD of the reflux group was shorter than the control group (t=2.049, P<0.05). The level of serum gastrin and plasma motilin of the reflux group was much lower than the control group (t=-2.230 and -2.235, P<0.05). There was positive correlation between the level of plasma motilin and SOBP and between the level of serum gastrin and SOBP and CBDP.CONCLUSION: About 35.9% of the patients with a T tube after cholecystectomy and choledochotomy have duodenal-biliary reflux. Most of them have sphincter of Oddi hypomotility and the decreased level of plasma motilin and serum gastrin. The disorder of gastrointestinal hormone secretion may result in sphincter of Oddi dysfunction. There is a close relationship between sphincter of Oddi hypomotility and duodenal-biliary reflux.
KeywordBILE-DUCT STONES GASTROINTESTINAL HORMONES ENDOSCOPIC SPHINCTEROTOMY MANOMETRY POSSUM FLOW sphincter of Oddi Tc99m-labeled diethylene triamine penta-acetic acid pressure motilin gastrin
Indexed ByCSCD
Language英语
CSCD IDCSCD:3317685
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/146187
Collection中国科学院金属研究所
Affiliation1.Shandong Prov Hosp, Department Hepatobiliary Surg, Jinan 250021, Shandong, Peoples R China
2.中国科学院金属研究所
3.Shandong Prov Hosp, Department Ophthalmol, Jinan 250021, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Zhang ZhenHai,Wu ShuoDong,Wang Bing,et al. Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(25):4077-4081.
APA Zhang ZhenHai.,Wu ShuoDong.,Wang Bing.,Su Yang.,Jin JunZhe.,...&Wang HaoLin.(2008).Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin.WORLD JOURNAL OF GASTROENTEROLOGY,14(25),4077-4081.
MLA Zhang ZhenHai,et al."Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin".WORLD JOURNAL OF GASTROENTEROLOGY 14.25(2008):4077-4081.
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