| Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines | |
| Alternative Title | Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines |
| Yu Fang1; Zhang Xiaojing1; Jiang Yongwen2 | |
| 2011 | |
| Source Publication | CHINESE JOURNAL OF CHEMISTRY
 |
| ISSN | 1001-604X |
| Volume | 29Issue:9Pages:1873-1879 |
| Abstract | A convenient and highly enantioselective method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and alpha-keto-alpha,beta-unsaturated esters, and subsequent reductive amination/condensation with primary amines. |
| Other Abstract | A convenient and highly enantioselective method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and α-keto-α,β-unsaturated esters, and subsequent reductive amination/condensation with primary amines. |
| Keyword | MICHAEL ADDITION 2,4-DISUBSTITUTED PIPERIDINES MULTICOMPONENT REACTIONS ALDEHYDES CYCLIZATION SCAFFOLDS ENTRY WATER organocatalysis Michael addition reductive amination substituted piperidine tetrahydropyridine |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] |
| CSCD ID | CSCD:4352577 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146210 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.中国科学院 |
| Recommended Citation GB/T 7714 | Yu Fang,Zhang Xiaojing,Jiang Yongwen. Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines[J]. CHINESE JOURNAL OF CHEMISTRY,2011,29(9):1873-1879. |
| APA | Yu Fang,Zhang Xiaojing,&Jiang Yongwen.(2011).Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines.CHINESE JOURNAL OF CHEMISTRY,29(9),1873-1879. |
| MLA | Yu Fang,et al."Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines".CHINESE JOURNAL OF CHEMISTRY 29.9(2011):1873-1879. |
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