Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines

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	Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines
其他题名	Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines
	Yu Fang 1; Zhang Xiaojing 1; Jiang Yongwen 2
	2011
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	29 期号:9 页码:1873-1879
摘要	A convenient and highly enantioselective method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and alpha-keto-alpha,beta-unsaturated esters, and subsequent reductive amination/condensation with primary amines.
其他摘要	A convenient and highly enantioselective method for assembly of functionalized 1,2,3,4,5-pentasubstituted tetrahydropyridines and piperidines was developed. This method relies on preparing the required enantiopure cyclic semi-acetals via an organocatalyzed Michael addition/cyclization cascade reaction of aldehydes and α-keto-α,β-unsaturated esters, and subsequent reductive amination/condensation with primary amines.
关键词	MICHAEL ADDITION 2,4-DISUBSTITUTED PIPERIDINES MULTICOMPONENT REACTIONS ALDEHYDES CYCLIZATION SCAFFOLDS ENTRY WATER organocatalysis Michael addition reductive amination substituted piperidine tetrahydropyridine
收录类别	CSCD
语种	英语
资助项目	[National Natural Science Foundation of China]
CSCD记录号	CSCD:4352577
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/146210
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院
推荐引用方式 GB/T 7714	Yu Fang,Zhang Xiaojing,Jiang Yongwen. Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines[J]. CHINESE JOURNAL OF CHEMISTRY,2011,29(9):1873-1879.
APA	Yu Fang,Zhang Xiaojing,&Jiang Yongwen.(2011).Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines.CHINESE JOURNAL OF CHEMISTRY,29(9),1873-1879.
MLA	Yu Fang,et al."Organocatalytically Enantioselective Approach to Polysubstituted Tetrahydropyridines and Piperidines".CHINESE JOURNAL OF CHEMISTRY 29.9(2011):1873-1879.