| Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities | |
| Mei YuDan1; Zhang Nan3; Zhang WeiYang4; Tang JinShan1; Zhou Hua4; Yu Yang1; Yao XinSheng1 | |
| 2019 | |
| Source Publication | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| ISSN | 2095-6975 |
| Volume | 17Issue:1Pages:27-32 |
| Abstract | The flower buds of Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of L. macranthoides resulted in the isolation of 12 triterpenoids (1-12), including two new ursane-type nortriterpenes, 2 alpha, 24-dihydroxy-23-nor-ursolic acid (1) and 2 alpha, 4 alpha-dihydroxy-23-nor-ursolic acid (2). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory effects on iNOS at the concentration of 30 mu mol.L-1. |
| Keyword | TRITERPENOID SAPONINS GLYCOSIDES BUDS STEMS Lonicerae Flos Lonicera macranthoides Ursane-type nortriterpenes Anti-inflammation iNOS |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Science and Technology Planning Project of Guangdong Province] |
| CSCD ID | CSCD:6416308 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146391 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院广州地球化学研究所 2.暨南大学 3.中国科学院金属研究所 4.Macau University Sci & Technol, Fac Chinese Med, Macau 999078, Peoples R China Fac Chinese Med 5.Macau University Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China State Key Lab Qual Res Chinese Med |
| Recommended Citation GB/T 7714 | Mei YuDan,Zhang Nan,Zhang WeiYang,et al. Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(1):27-32. |
| APA | Mei YuDan.,Zhang Nan.,Zhang WeiYang.,Tang JinShan.,Zhou Hua.,...&Yao XinSheng.(2019).Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities.CHINESE JOURNAL OF NATURAL MEDICINES,17(1),27-32. |
| MLA | Mei YuDan,et al."Two new ursane-type nortriterpenes from Lonicera macranthoides and their iNOS-inhibitory activities".CHINESE JOURNAL OF NATURAL MEDICINES 17.1(2019):27-32. |
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