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Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China
Alternative TitleAssociation of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin,Liaoning,China
Hao Ying; Wu Baogang; Shi Jin; Chen Yanli; Sun Zhaoqing; Zheng Liqiang; Zhang Xingang; Geng Ning; Li Tiejun; Li Hong; Sun Yingxian
2011
Source PublicationCHINESE MEDICAL JOURNAL
ISSN0366-6999
Volume124Issue:14Pages:2113-2116
AbstractBackground Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase (GPx-3) tag single nucleotide polymorphisms (SNPs) are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China.
Other AbstractBackground Genetic mechanisms contribute to blood pressure regulation.This study investigated whether glutathione peroxidase (GPx-3)tag single nucleotide polymorphisms (SNPs)are associated with hypertension in the rural areas of Fuxin county,Liaoning province,China.Methods Indigenous Fuxin Han people participated,523 unrelated hypertensives and 547 controls were recruited.All tag SNPs of GPx-3 gene were selected.We estimated SNP allele frequency in DNA pools with pyrosequencing.Results Before Bonferroni correction,C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs.19.3%,P=0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs.40.8%,P=0.009).However,when a Bonferroni correction for multiple testing was applied,only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P=0.045,OR:0.833,95% Cl:0.695-0.998).Conclusion The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin,Liaoning.
KeywordSALT-SENSITIVE HYPERTENSION ARTERIAL ISCHEMIC-STROKE PROMOTER POLYMORPHISMS ALLELE FREQUENCY OXIDATIVE STRESS BLOOD-PRESSURE RISK-FACTOR DNA POOLS PEROXIDASE GENE hypertension Han Chinese GPx-3 gene association
Indexed ByCSCD
Language英语
Funding Project[Ministry of Science and Technology, China]
CSCD IDCSCD:4319811
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147027
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Hao Ying,Wu Baogang,Shi Jin,et al. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China[J]. CHINESE MEDICAL JOURNAL,2011,124(14):2113-2116.
APA Hao Ying.,Wu Baogang.,Shi Jin.,Chen Yanli.,Sun Zhaoqing.,...&Sun Yingxian.(2011).Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China.CHINESE MEDICAL JOURNAL,124(14),2113-2116.
MLA Hao Ying,et al."Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China".CHINESE MEDICAL JOURNAL 124.14(2011):2113-2116.
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