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The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis
Alternative TitleThe cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis
Xu Hui1; Yuan ShuiQiao1; Zheng ZhiHong1; Yan Wei1
2013
Source PublicationASIAN JOURNAL OF ANDROLOGY
ISSN1008-682X
Volume15Issue:6Pages:799-805
AbstractAlthough the cytoplasm of spermatids is removed at the end of spermiogenesis, a tiny portion is usually retained in the sperm flagellum, which is termed the cytoplasmic droplet (CD) in mammals. CDs are believed to play a role in sperm volume adaptation. However, we have noticed that epididymal spermatozoa that display initial (flagellation in situ) and progressive motility mostly possess CDs, whereas spermatozoa without CDs are rarely motile, suggesting that CDs have a role in motility development during sperm epididymal maturation. In the present study, we analyzed the relationship between the presence or absence of CDs, motility development and positional changes of CDs during sperm epididymal maturation in mice and monkeys. We also examined CDs on spermatozoa of three knockout mouse lines with late spermiogenic defects. Our data suggest that the CD is a normal organelle transiently present exclusively on epididymal spermatozoa, and normal CD morphology and location are associated with normal motility development during epididymal maturation of spermatozoa. Abnormal CD formation, e.g., a complete lack of CDs or ectopic CDs, is indicative of defective spermiogenesis. If CDs are essential for sperm motility development, then CDs may represent an ideal drug target for the development of non-hormonal male contraceptives.
Other AbstractAlthough the cytoplasm of spermatids is removed at the end of spermiogenesis, a tiny portion is usually retained in the sperm flagellum, which is termed the cytoplasmic droplet (CD) in mammals. CDs are believed to play a role in sperm volume adaptation. However, we have noticed that epididymal spermatozoa that display initial (flagellation in situ ) and progressive motility mostly possess CDs, whereas spermatozoa without CDs are rarely motile, suggesting that CDs have a role in motility development during sperm epididymal maturation. In the present study, we analyzed the relationship between the presence or absence of CDs, motility development and positional changes of CDs during sperm epididymal maturation in mice and monkeys. We also examined CDs on spermatozoa of three knockout mouse lines with late spermiogenic defects. Our data suggest that the CD is a normal organelle transiently present exclusively on epididymal spermatozoa, and normal CD morphology and location are associated with normal motility development during epididymal maturation of spermatozoa. Abnormal CD formation, e.g., a complete lack of CDs or ectopic CDs, is indicative of defective spermiogenesis. If CDs are essential for sperm motility development, then CDs may represent an ideal drug target for the development of non-hormonal male contraceptives.
KeywordHUMAN SPERMATOZOA ALKALINE-PHOSPHATASE VOLUME REGULATION MALE-INFERTILITY LIFE-HISTORY RAT SPERMATOGENESIS EPIDIDYMIS ENZYMES MOUSE cytoplasmic droplets epididymis fertility mouse semen analysis spermiogenesis sperm motility
Indexed ByCSCD
Language英语
Funding Project[startup funds from the University of Nevada, Reno]
CSCD IDCSCD:4960262
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147138
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.华东师范大学
Recommended Citation
GB/T 7714
Xu Hui,Yuan ShuiQiao,Zheng ZhiHong,et al. The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis[J]. ASIAN JOURNAL OF ANDROLOGY,2013,15(6):799-805.
APA Xu Hui,Yuan ShuiQiao,Zheng ZhiHong,&Yan Wei.(2013).The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis.ASIAN JOURNAL OF ANDROLOGY,15(6),799-805.
MLA Xu Hui,et al."The cytoplasmic droplet may be indicative of sperm motility and normal spermiogenesis".ASIAN JOURNAL OF ANDROLOGY 15.6(2013):799-805.
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