| Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid | |
| Alternative Title | Synthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid |
| Liu Dan1; Meng Yanqiu2; Zhao Juan2; Chen Ligong1 | |
| 2008 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 24Issue:1Pages:42-46 |
| Abstract | Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, H-1 NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group. |
| Other Abstract | Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ~1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group. |
| Keyword | BETULINIC ACID HUMAN-MELANOMA CELLS INHIBITION APOPTOSIS DNA ursolic acid amide derivatives anti-tumor activity |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3251191 |
| Citation statistics |
Cited Times:11[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/147210 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Tianjin Univ, Coll Pharmaceut & Biotechnology, Tianjin 300072, Peoples R China 2.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Liu Dan,Meng Yanqiu,Zhao Juan,et al. Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):42-46. |
| APA | Liu Dan,Meng Yanqiu,Zhao Juan,&Chen Ligong.(2008).Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),42-46. |
| MLA | Liu Dan,et al."Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):42-46. |
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