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Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid
Alternative TitleSynthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid
Liu Dan1; Meng Yanqiu2; Zhao Juan2; Chen Ligong1
2008
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume24Issue:1Pages:42-46
AbstractUrsolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, H-1 NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.
Other AbstractUrsolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ~1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.
KeywordBETULINIC ACID HUMAN-MELANOMA CELLS INHIBITION APOPTOSIS DNA ursolic acid amide derivatives anti-tumor activity
Indexed ByCSCD
Language英语
CSCD IDCSCD:3251191
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147210
Collection中国科学院金属研究所
Affiliation1.Tianjin Univ, Coll Pharmaceut & Biotechnology, Tianjin 300072, Peoples R China
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Liu Dan,Meng Yanqiu,Zhao Juan,et al. Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):42-46.
APA Liu Dan,Meng Yanqiu,Zhao Juan,&Chen Ligong.(2008).Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),42-46.
MLA Liu Dan,et al."Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):42-46.
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