Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid

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	Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid
其他题名	Synthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid
	Liu Dan 1; Meng Yanqiu 2; Zhao Juan 2; Chen Ligong 1
	2008
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	24 期号:1 页码:42-46
摘要	Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, H-1 NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.
其他摘要	Ursolic acid was modified at C3 and C28 position to obtain fourteen derivatives including twelve novel compounds, and their chemical structures were characterized by IR, ~1H NMR and MS. Cell growth inhibitory effects of the derivatives against Hela cell were evaluated by MTT assay. All these derivatives were found to have stronger cell growth inhibitory than their parent compound, ursolic acid. The derivatives with a substituted acetyl group at C3 hydroxyl group show better activities than those with an unsubstituted hydroxyl group.
关键词	BETULINIC ACID HUMAN-MELANOMA CELLS INHIBITION APOPTOSIS DNA ursolic acid amide derivatives anti-tumor activity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3251191
引用统计	被引频次：11[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147210
专题	中国科学院金属研究所
作者单位	1.Tianjin Univ, Coll Pharmaceut & Biotechnology, Tianjin 300072, Peoples R China 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Liu Dan,Meng Yanqiu,Zhao Juan,et al. Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):42-46.
APA	Liu Dan,Meng Yanqiu,Zhao Juan,&Chen Ligong.(2008).Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),42-46.
MLA	Liu Dan,et al."Synthesis and anti-tumor activity of novel amide derivatives of ursolic acid".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):42-46.