Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice

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	Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
其他题名	Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
	Liu YL 1; Liang JH 1; Yan LD 1; Su RB 1; Wu CF 1; Gong ZH 1
	2005
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	1671-4083
卷号	26 期号:5 页码:533-538
摘要	Aim: Recent studies have shown that 1-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.
其他摘要	Aim: Recent studies have shown that l-tetrahydropalmatine (l-THP), an active component of Corydolis yanhusuo, can inhibit the development of the conditional place preference induced by opioid receptor agonists, but the effects of l-THP on locomotor sensitivity induced by opioid receptor agonists have not been documented. In the present study, the effects of l-THP on locomotor sensitization to oxycodone, which is an opioid receptor agonist, were studied. Methods: Mice treated daily for 7 d with 5 mg/kg oxycodone and challenged with the same dose after 5 days of washout showed locomotor sensitization. In order to study the effects of l-THP on locomotor sensitization induced by oxycodone, l-THP was administered at doses of 6.25, 12.5, and 18.75 mg/kg, 40 min prior to treatment of oxycodone. Results: l-THP per se did not affect the locomotor activity at the doses of 6.25, 12.5, and 18.75 mg/kg, but could antagonize the hyperactivity induced by oxycodone (5 mg/kg). Co-administration of l-THP (18.75 mg/kg), 40 min prior to oxycodone, could inhibit the development of sensitization to oxycodone. In addition, l-THP (6.25, 12.5, and 18.75 mg/kg, ig) dose-dependently prevented the expression of oxycodone sensitization. Conclusion: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization.
关键词	DOPAMINE-RECEPTOR ANTAGONISTS CALCIUM-CHANNEL INHIBITORS BEHAVIORAL SENSITIZATION MORPHINE EXPRESSION ADDICTION COCAINE RATS BLOCKERS HEROIN l-tetrahydropalmatine oxycodone locomotor sensitization
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:2038650
引用统计	被引频次：6[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147301
专题	中国科学院金属研究所
作者单位	1.Beijing Institute Pharmacol & Toxicol 2.中国科学院金属研究所 3.北京大学
推荐引用方式 GB/T 7714	Liu YL,Liang JH,Yan LD,et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice[J]. ACTA PHARMACOLOGICA SINICA,2005,26(5):533-538.
APA	Liu YL,Liang JH,Yan LD,Su RB,Wu CF,&Gong ZH.(2005).Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice.ACTA PHARMACOLOGICA SINICA,26(5),533-538.
MLA	Liu YL,et al."Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice".ACTA PHARMACOLOGICA SINICA 26.5(2005):533-538.