Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray

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	Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray
其他题名	Expression of Elk-1 in Non-Small Cell Lung Cancer Detected by Western Blot and Tissue Microarray
	Zhang Shuguang 1; Li Fang 2; Li Wenya 1; Lu Wei 1; Zhang Lin 1
	2007
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	19 期号:1 页码:7-11
摘要	Objective: The aim of this study was to investigate the Elk- 1 ( Ets like transcription factor- 1) expression in non- small cell lung cancer ( NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk- 1 expression, western blot and immunochemistry ( IHC) on tissue microarray ( TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk- 1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk- 1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group ( I+ II) than in advanced stage group ( III), and lower in well- moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk- 1 expression, and Elk- 1 may be regarded as a prognostic factor for NSCLC tissues.
其他摘要	Objective: The aim of this study was to investigate the Elk-1 (Ets like transcription factor-1) expression in non-small cell lung cancer (NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk-1 expression, western blot and immunochemistry (IHC) on tissue microarray (TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk-1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk-1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group (I+II) than in advanced stage group (III), and lower in well-moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk-1 expression, and Elk-1 may be regarded as a prognostic factor for NSCLC tissues.
关键词	TERNARY COMPLEX FACTORS TRANSCRIPTION FACTORS ETS Elk-1 non-small cell lung cancer western blot immunohistochemistry tissue microarray
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:2920359
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147428
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Chinese Acad Med Sci, Dept Thorac Surg, Institute Canc, Beijing 100021, Peoples R China Dept Thorac Surg Institute Canc 3.中国医学科学院 4.Peking Union Med Coll, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Zhang Shuguang,Li Fang,Li Wenya,et al. Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(1):7-11.
APA	Zhang Shuguang,Li Fang,Li Wenya,Lu Wei,&Zhang Lin.(2007).Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray.CHINESE JOURNAL OF CANCER RESEARCH,19(1),7-11.
MLA	Zhang Shuguang,et al."Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray".CHINESE JOURNAL OF CANCER RESEARCH 19.1(2007):7-11.