| Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor | |
| He Haihong1; He Tingting1; Zhang Ziqian2; Xu Xiu1; Yang Huibin3; Qian Xuhong4; Yang Youjun4 | |
| 2018 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 29Issue:10Pages:1497-1499 |
| Abstract | Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs). (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| Other Abstract | Nitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs). |
| Keyword | MITOCHONDRIAL DYNAMICS PHOTON NO donor Photo-trigger Photo-calibrate Platelet aggregation inhibition Antimicrobial |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; [Fundamental Research Funds for the Central Universities] |
| CSCD ID | CSCD:6346033 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/147813 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.陕西省地震局 2.广西大学 3.中国科学院金属研究所 4.East China University Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China |
| Recommended Citation GB/T 7714 | He Haihong,He Tingting,Zhang Ziqian,et al. Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor[J]. CHINESE CHEMICAL LETTERS,2018,29(10):1497-1499. |
| APA | He Haihong.,He Tingting.,Zhang Ziqian.,Xu Xiu.,Yang Huibin.,...&Yang Youjun.(2018).Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor.CHINESE CHEMICAL LETTERS,29(10),1497-1499. |
| MLA | He Haihong,et al."Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor".CHINESE CHEMICAL LETTERS 29.10(2018):1497-1499. |
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