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Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor
He Haihong1; He Tingting1; Zhang Ziqian2; Xu Xiu1; Yang Huibin3; Qian Xuhong4; Yang Youjun4
2018
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume29Issue:10Pages:1497-1499
AbstractNitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs). (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Other AbstractNitric oxide (NO) donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release. Inspired by this discovery, we developed a fast-releasing NO donor (NOD575) suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells (PASMCs).
KeywordMITOCHONDRIAL DYNAMICS PHOTON NO donor Photo-trigger Photo-calibrate Platelet aggregation inhibition Antimicrobial
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Fundamental Research Funds for the Central Universities]
CSCD IDCSCD:6346033
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147815
Collection中国科学院金属研究所
Affiliation1.陕西省地震局
2.广西大学
3.中国科学院金属研究所
4.East China University Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
He Haihong,He Tingting,Zhang Ziqian,et al. Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor[J]. CHINESE CHEMICAL LETTERS,2018,29(10):1497-1499.
APA He Haihong.,He Tingting.,Zhang Ziqian.,Xu Xiu.,Yang Huibin.,...&Yang Youjun.(2018).Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor.CHINESE CHEMICAL LETTERS,29(10),1497-1499.
MLA He Haihong,et al."Ring-restricted N-nitrosated rhodamine as a green-light triggered, orange-emission calibrated and fast-releasing nitric oxide donor".CHINESE CHEMICAL LETTERS 29.10(2018):1497-1499.
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