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Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents
Alternative TitleSynthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents
Guo Shuchun; Zhao Yanfang; Li Rongdong; Xie Lijun; Yang Youbin; Gong Ping
2008
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume24Issue:1Pages:47-53
AbstractA series of novel alkylthio/sulfinyl-8H-thieno2,3-bpyrrolizin-8-oximino derivatives V-1-VIII15 were designed and synthesized as antitumor agents. Their structures were confirmed using IF, H-1 NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound VI9 displayed a promising antitumor activity superior to that of Cisplatin.
Other AbstractA series of novel alkylthio/sulfinyl-8H-thieno2,3-bpyrrolizin-8-oximino derivatives Ⅴ_1--Ⅷ_(15) were designed and synthesized as antitumor agents. Their structures were confirmed using IR, ~1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound Ⅵ_9 displayed a promising antitumor activity superior to that of Cisplatin.
KeywordANTITUBULIN AGENTS DESIGN thieno2,3-b pyrrolizine synthesis antitumor activity
Indexed ByCSCD
Language英语
CSCD IDCSCD:3251192
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/147880
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Guo Shuchun,Zhao Yanfang,Li Rongdong,et al. Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):47-53.
APA Guo Shuchun,Zhao Yanfang,Li Rongdong,Xie Lijun,Yang Youbin,&Gong Ping.(2008).Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),47-53.
MLA Guo Shuchun,et al."Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):47-53.
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