| Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents | |
| Alternative Title | Synthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents |
| Guo Shuchun; Zhao Yanfang; Li Rongdong; Xie Lijun; Yang Youbin; Gong Ping | |
| 2008 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 24Issue:1Pages:47-53 |
| Abstract | A series of novel alkylthio/sulfinyl-8H-thieno2,3-bpyrrolizin-8-oximino derivatives V-1-VIII15 were designed and synthesized as antitumor agents. Their structures were confirmed using IF, H-1 NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound VI9 displayed a promising antitumor activity superior to that of Cisplatin. |
| Other Abstract | A series of novel alkylthio/sulfinyl-8H-thieno2,3-bpyrrolizin-8-oximino derivatives Ⅴ_1--Ⅷ_(15) were designed and synthesized as antitumor agents. Their structures were confirmed using IR, ~1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound Ⅵ_9 displayed a promising antitumor activity superior to that of Cisplatin. |
| Keyword | ANTITUBULIN AGENTS DESIGN thieno2,3-b pyrrolizine synthesis antitumor activity |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3251192 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/147880 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Guo Shuchun,Zhao Yanfang,Li Rongdong,et al. Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):47-53. |
| APA | Guo Shuchun,Zhao Yanfang,Li Rongdong,Xie Lijun,Yang Youbin,&Gong Ping.(2008).Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),47-53. |
| MLA | Guo Shuchun,et al."Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):47-53. |
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