Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents

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	Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents
其他题名	Synthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents
	Guo Shuchun; Zhao Yanfang; Li Rongdong; Xie Lijun; Yang Youbin; Gong Ping
	2008
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	24 期号:1 页码:47-53
摘要	A series of novel alkylthio/sulfinyl-8H-thieno2,3-bpyrrolizin-8-oximino derivatives V-1-VIII15 were designed and synthesized as antitumor agents. Their structures were confirmed using IF, H-1 NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound VI9 displayed a promising antitumor activity superior to that of Cisplatin.
其他摘要	A series of novel alkylthio/sulfinyl-8H-thieno2,3-bpyrrolizin-8-oximino derivatives Ⅴ_1--Ⅷ_(15) were designed and synthesized as antitumor agents. Their structures were confirmed using IR, ~1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound Ⅵ_9 displayed a promising antitumor activity superior to that of Cisplatin.
关键词	ANTITUBULIN AGENTS DESIGN thieno2,3-b pyrrolizine synthesis antitumor activity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3251192
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/147880
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Guo Shuchun,Zhao Yanfang,Li Rongdong,et al. Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2008,24(1):47-53.
APA	Guo Shuchun,Zhao Yanfang,Li Rongdong,Xie Lijun,Yang Youbin,&Gong Ping.(2008).Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,24(1),47-53.
MLA	Guo Shuchun,et al."Synthesis and biological evaluation of novel tricyclic oximino derivatives as antitumor agents".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 24.1(2008):47-53.