| Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety | |
| Alternative Title | Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety |
| Xu Boxuan1; Ding Xiudong2; Wu Yachuang1; Cui Lei2; Qian Ping1; Wang Di2; Zhao Yanfang1 | |
| 2018 | |
| Source Publication | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| ISSN | 1005-9040 |
| Volume | 34Issue:1Pages:51-56 |
| Abstract | A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of H-1 NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control. |
| Other Abstract | A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ~1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds lOe and lOf displayed better activity than the control. |
| Keyword | AGENTS DISCOVERY SAR Oxazolidinone derivative Antibacterial activity Linezolid Ranbezolid |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China] ; [Basic Program of Liaoning Provincial Department of Education, China] |
| CSCD ID | CSCD:6163249 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/148314 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.中国科学院金属研究所 2.309th Hosp PLA, Department Clin Lab, Beijing 100091, Peoples R China |
| Recommended Citation GB/T 7714 | Xu Boxuan,Ding Xiudong,Wu Yachuang,et al. Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2018,34(1):51-56. |
| APA | Xu Boxuan.,Ding Xiudong.,Wu Yachuang.,Cui Lei.,Qian Ping.,...&Zhao Yanfang.(2018).Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,34(1),51-56. |
| MLA | Xu Boxuan,et al."Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 34.1(2018):51-56. |
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