Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety

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	Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety
其他题名	Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety
	Xu Boxuan 1; Ding Xiudong 2; Wu Yachuang 1; Cui Lei 2; Qian Ping 1; Wang Di 2; Zhao Yanfang 1
	2018
发表期刊	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
卷号	34 期号:1 页码:51-56
摘要	A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of H-1 NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.
其他摘要	A series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ~1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds lOe and lOf displayed better activity than the control.
关键词	AGENTS DISCOVERY SAR Oxazolidinone derivative Antibacterial activity Linezolid Ranbezolid
收录类别	CSCD
语种	英语
资助项目	[Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China] ; [Basic Program of Liaoning Provincial Department of Education, China]
CSCD记录号	CSCD:6163249
引用统计	被引频次：2[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148314
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.309th Hosp PLA, Department Clin Lab, Beijing 100091, Peoples R China
推荐引用方式 GB/T 7714	Xu Boxuan,Ding Xiudong,Wu Yachuang,et al. Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2018,34(1):51-56.
APA	Xu Boxuan.,Ding Xiudong.,Wu Yachuang.,Cui Lei.,Qian Ping.,...&Zhao Yanfang.(2018).Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,34(1),51-56.
MLA	Xu Boxuan,et al."Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 34.1(2018):51-56.