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Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety
Alternative TitleSynthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety
Xu Boxuan1; Ding Xiudong2; Wu Yachuang1; Cui Lei2; Qian Ping1; Wang Di2; Zhao Yanfang1
2018
Source PublicationCHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN1005-9040
Volume34Issue:1Pages:51-56
AbstractA series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of H-1 NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds 10e and 10f displayed better activity than the control.
Other AbstractA series of novel oxazolidinone derivatives containing nitro heteroaromatic moiety was synthesized and characterized by means of ~1H NMR and MS spectra. All target compounds were evaluated for their in vitro antibacterial activities against S.au 29213, methicillin-resistant Staphylococcus aureus(MRSA) and vancomycin-resistant Enterococcus(VRE) by minimum inhibitory concentration(MIC) assay. Most of them exhibited antibacterial activity against S. au 29213, MRSA and VRE. Among them, compounds lOe and lOf displayed better activity than the control.
KeywordAGENTS DISCOVERY SAR Oxazolidinone derivative Antibacterial activity Linezolid Ranbezolid
Indexed ByCSCD
Language英语
Funding Project[Program for Innovative Research Team of the Ministry of Education of China] ; [Program for Liaoning Innovative Research Team in University, China] ; [Basic Program of Liaoning Provincial Department of Education, China]
CSCD IDCSCD:6163249
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148314
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.309th Hosp PLA, Department Clin Lab, Beijing 100091, Peoples R China
Recommended Citation
GB/T 7714
Xu Boxuan,Ding Xiudong,Wu Yachuang,et al. Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2018,34(1):51-56.
APA Xu Boxuan.,Ding Xiudong.,Wu Yachuang.,Cui Lei.,Qian Ping.,...&Zhao Yanfang.(2018).Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,34(1),51-56.
MLA Xu Boxuan,et al."Synthesis and Antibacterial Activity of Oxazolidinone Derivatives Containing Nitro Heteroaromatic Moiety".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 34.1(2018):51-56.
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