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Design, synthesis and biological evaluation of novel glucokinase activators
Alternative TitleDesign, synthesis and biological evaluation of novel glucokinase activators
Li Yong Qiang1; Zhang Yu Liang3; Hu Sheng Quan3; Wang Yu Ling3; Song Hong Rui3; Feng Zhi Qiang1; Lei Lei1; Liu Quan1; Shen Zhu Fang1
2011
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume22Issue:1Pages:73-76
AbstractA new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675. (C) 2010 Zhi Qiang Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675
KeywordDISCOVERY POTENT Diabetes Glucokinase activators Benzamide derivatives
Indexed ByCSCD
Language英语
Funding Project[National Nature Science Foundation of China]
CSCD IDCSCD:4122342
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148335
Collection中国科学院金属研究所
Affiliation1.Chinese Acad Med Sci, Institute Mat Med, Beijing 100050, Peoples R China Institute Mat Med
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.中国科学院金属研究所
Recommended Citation
GB/T 7714
Li Yong Qiang,Zhang Yu Liang,Hu Sheng Quan,et al. Design, synthesis and biological evaluation of novel glucokinase activators[J]. CHINESE CHEMICAL LETTERS,2011,22(1):73-76.
APA Li Yong Qiang.,Zhang Yu Liang.,Hu Sheng Quan.,Wang Yu Ling.,Song Hong Rui.,...&Shen Zhu Fang.(2011).Design, synthesis and biological evaluation of novel glucokinase activators.CHINESE CHEMICAL LETTERS,22(1),73-76.
MLA Li Yong Qiang,et al."Design, synthesis and biological evaluation of novel glucokinase activators".CHINESE CHEMICAL LETTERS 22.1(2011):73-76.
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