Design, synthesis and biological evaluation of novel glucokinase activators

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	Design, synthesis and biological evaluation of novel glucokinase activators
其他题名	Design, synthesis and biological evaluation of novel glucokinase activators
	Li Yong Qiang 1; Zhang Yu Liang 3; Hu Sheng Quan 3; Wang Yu Ling 3; Song Hong Rui 3; Feng Zhi Qiang 1; Lei Lei 1; Liu Quan 1; Shen Zhu Fang 1
	2011
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	22 期号:1 页码:73-76
摘要	A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675. (C) 2010 Zhi Qiang Feng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship (SAR) is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675
关键词	DISCOVERY POTENT Diabetes Glucokinase activators Benzamide derivatives
收录类别	CSCD
语种	英语
资助项目	[National Nature Science Foundation of China]
CSCD记录号	CSCD:4122342
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148338
专题	中国科学院金属研究所
作者单位	1.Chinese Acad Med Sci, Institute Mat Med, Beijing 100050, Peoples R China Institute Mat Med 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Li Yong Qiang,Zhang Yu Liang,Hu Sheng Quan,et al. Design, synthesis and biological evaluation of novel glucokinase activators[J]. CHINESE CHEMICAL LETTERS,2011,22(1):73-76.
APA	Li Yong Qiang.,Zhang Yu Liang.,Hu Sheng Quan.,Wang Yu Ling.,Song Hong Rui.,...&Shen Zhu Fang.(2011).Design, synthesis and biological evaluation of novel glucokinase activators.CHINESE CHEMICAL LETTERS,22(1),73-76.
MLA	Li Yong Qiang,et al."Design, synthesis and biological evaluation of novel glucokinase activators".CHINESE CHEMICAL LETTERS 22.1(2011):73-76.