| Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism | |
| Alternative Title | Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism |
| Yuan HengJie1; Chen DaWei3; Ren Yun1; Lou JianShi2 | |
| 2008 | |
| Source Publication | ACTA CHIMICA SINICA
 |
| ISSN | 0567-7351 |
| Volume | 66Issue:21Pages:2429-2433 |
| Abstract | Theoretical conversion temperature was calculated between different crystal forms of nitrendipine from melting data. The different conversion conditions were investigated, such as high temperature, high temperature and humidity and high pressure. The theoretical conversion temperature between nitrendipine I and II is 158.88 degrees C, that between nitrendipine I and III is 160.50 degrees C and that between nitrendipine II and III is 159.65 degrees C, indicating nitrendipine polymorphs belong to a monotropic system. At high temperature, nitrendipine II and III both converted to I. Under high pressure, II converted to I. The results indicate that nitrendipine I was a stable form, while II and III were metastable form. The stability ranked as I>II>III. Keywords nitrendipine; crystal polymorph; conversion; X-ray diffraction |
| Keyword | nitrendipine crystal polymorph conversion X-ray diffraction |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3459506 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/148536 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Tianjin Med University, Gen Hosp, Dept Pharm, Tianjin 300052, Peoples R China 2.安徽肥东花生原种场 3.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Yuan HengJie,Chen DaWei,Ren Yun,et al. Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism[J]. ACTA CHIMICA SINICA,2008,66(21):2429-2433. |
| APA | Yuan HengJie,Chen DaWei,Ren Yun,&Lou JianShi.(2008).Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism.ACTA CHIMICA SINICA,66(21),2429-2433. |
| MLA | Yuan HengJie,et al."Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism".ACTA CHIMICA SINICA 66.21(2008):2429-2433. |
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