Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism

IMR OpenIR

	Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism
其他题名	Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism
	Yuan HengJie 1; Chen DaWei 3; Ren Yun 1; Lou JianShi 2
	2008
发表期刊	ACTA CHIMICA SINICA
ISSN	0567-7351
卷号	66 期号:21 页码:2429-2433
摘要	Theoretical conversion temperature was calculated between different crystal forms of nitrendipine from melting data. The different conversion conditions were investigated, such as high temperature, high temperature and humidity and high pressure. The theoretical conversion temperature between nitrendipine I and II is 158.88 degrees C, that between nitrendipine I and III is 160.50 degrees C and that between nitrendipine II and III is 159.65 degrees C, indicating nitrendipine polymorphs belong to a monotropic system. At high temperature, nitrendipine II and III both converted to I. Under high pressure, II converted to I. The results indicate that nitrendipine I was a stable form, while II and III were metastable form. The stability ranked as I>II>III. Keywords nitrendipine; crystal polymorph; conversion; X-ray diffraction
关键词	nitrendipine crystal polymorph conversion X-ray diffraction
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3459506
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148536
专题	中国科学院金属研究所
作者单位	1.Tianjin Med University, Gen Hosp, Dept Pharm, Tianjin 300052, Peoples R China 2.安徽肥东花生原种场 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Yuan HengJie,Chen DaWei,Ren Yun,et al. Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism[J]. ACTA CHIMICA SINICA,2008,66(21):2429-2433.
APA	Yuan HengJie,Chen DaWei,Ren Yun,&Lou JianShi.(2008).Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism.ACTA CHIMICA SINICA,66(21),2429-2433.
MLA	Yuan HengJie,et al."Conversion Conditions and Influence Factors of Nitrendipine Crystal Polymorphism".ACTA CHIMICA SINICA 66.21(2008):2429-2433.