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Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions
Alternative TitleSignificance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions
Zhang JianGuo; Zhao Jing; Xin Yan
2010
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume16Issue:5Pages:571-577
AbstractAIM: To explore the relationship between Cripto-1 (CR-1) and tyrosine phosphorylation STAT3 (p-STAT3) expressions in gastric cancer (GC) and gastric carcinogensis and metastasis.
Other AbstractAIM: To explore the relationship between Cripto-1 (CR-1) and tyrosine phosphorylation STAT3 (p-STAT3) expressions in gastric cancer (GC) and gastric carcinogensis and metastasis.METHODS: The PV9000 immunohistochemical method was used to detect the expression of CR-1 and p-STAT3 in 178 cases of GC, 95 matched normal gastric mucosa, 40 chronic atrophic gastritis (CAG), 48 intestinal metaplasia (IM) and 25 dysplasia (DYS).RESULTS: The positive rates of CR-1 and p-STAT3 expression were significantly higher in CAG (65.0% and 60.0%), in IM (83.3% and 77.1%), DYS (80.0% and 68%) and GC (71.3% and 60.1%) than in normal gastric mucosa (43.2% and 41.1%, P < 0.05), respectively.The expressions of CR-1 and p-STAT3 (78.3% and 66.7%) were significantly higher in GC with lymph node metastasis than in those without metastasis (53.1% and 42.9%, P < 0.05). CR-1 expression was ( P < 0.001). Furthermore, there was positive relationship between CR-1 and p-STAT3 expressions in GC ( r_k =0.189, P = 0.002).CONCLUSION: The up-regulation of CR-1 and p-STAT3 may play important roles in gastric carcinogenesis and lymph node metastasis. CR-1 and p-STAT3 expression in GC was positively correlated, and the relevant molecular mechanism requires further investigations.
KeywordGROWTH-FACTOR SIGNAL TRANSDUCERS CELL-SURFACE ACTIVATION STATS ADENOCARCINOMA TRANSCRIPTION ONCOGENESIS PROGRESSION INHIBITION Cripto-1 Phosphorylation STAT3 Gastric cancer Precancerous lesions Immunohistochemistry
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China] ; [Special Fund for Climbing Scholars of Universities in Liaoning Province, China]
CSCD IDCSCD:3821174
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148543
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang JianGuo,Zhao Jing,Xin Yan. Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(5):571-577.
APA Zhang JianGuo,Zhao Jing,&Xin Yan.(2010).Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions.WORLD JOURNAL OF GASTROENTEROLOGY,16(5),571-577.
MLA Zhang JianGuo,et al."Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions".WORLD JOURNAL OF GASTROENTEROLOGY 16.5(2010):571-577.
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