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Expression of SKP2 protein in lung carcinoma
Alternative TitleExpression of SKP2 protein in lung carcinoma
Zhao Jun1; Yang Chunlu1; Zhang Huan2; Ding Weizhong1; Liu Zhiping1; Liu Jingyi1
2008
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume20Issue:3Pages:216-221
AbstractObjective: To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods: The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results: The positive rate of SKP2 protein staining was (23.52 +/- 13.57)% in non small cell lung carcinoma and (53.85 +/- 12.26)% in small cell lung carcinoma, which were significantly higher than (2.91 +/- 1.27)% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them (P=0.000). The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group (P-1=0.003/0.002; r=-0.275, P-2=0.005). Conclusion: The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.
Other AbstractObjective To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results The positive rate of SKP2 protein staining was (23.52±13.57)% in non small cell lung carcinoma and (53.85±12.26)% in small cell lung carcinoma, which were significantly higher than (2.91±1.27)% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them (P=0.000). The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group (P_1=0.003/0.002; r=0.275, P_2=0.005).Conclusion The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.
KeywordS-PHASE KINASE DOWN-REGULATION CANCER CELLS GENE OVEREXPRESSION RNA P27 ADENOCARCINOMA AMPLIFICATION DEGRADATION lung carcinoma SKP2 protein Tissue Chip Immunohistochemistry
Indexed ByCSCD
Language英语
CSCD IDCSCD:3360145
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148694
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.MCH Hosp Tanggu Dist Tianjin City, Ctr Supersound, Tianjin 300451, Peoples R China
Recommended Citation
GB/T 7714
Zhao Jun,Yang Chunlu,Zhang Huan,et al. Expression of SKP2 protein in lung carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(3):216-221.
APA Zhao Jun,Yang Chunlu,Zhang Huan,Ding Weizhong,Liu Zhiping,&Liu Jingyi.(2008).Expression of SKP2 protein in lung carcinoma.CHINESE JOURNAL OF CANCER RESEARCH,20(3),216-221.
MLA Zhao Jun,et al."Expression of SKP2 protein in lung carcinoma".CHINESE JOURNAL OF CANCER RESEARCH 20.3(2008):216-221.
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