Expression of SKP2 protein in lung carcinoma

IMR OpenIR

	Expression of SKP2 protein in lung carcinoma
其他题名	Expression of SKP2 protein in lung carcinoma
	Zhao Jun 1; Yang Chunlu 1; Zhang Huan 2; Ding Weizhong 1; Liu Zhiping 1; Liu Jingyi 1
	2008
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	20 期号:3 页码:216-221
摘要	Objective: To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods: The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results: The positive rate of SKP2 protein staining was (23.52 +/- 13.57)% in non small cell lung carcinoma and (53.85 +/- 12.26)% in small cell lung carcinoma, which were significantly higher than (2.91 +/- 1.27)% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them (P=0.000). The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group (P-1=0.003/0.002; r=-0.275, P-2=0.005). Conclusion: The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.
其他摘要	Objective To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results The positive rate of SKP2 protein staining was (23.52±13.57)% in non small cell lung carcinoma and (53.85±12.26)% in small cell lung carcinoma, which were significantly higher than (2.91±1.27)% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them (P=0.000). The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group (P_1=0.003/0.002; r=0.275, P_2=0.005).Conclusion The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.
关键词	S-PHASE KINASE DOWN-REGULATION CANCER CELLS GENE OVEREXPRESSION RNA P27 ADENOCARCINOMA AMPLIFICATION DEGRADATION lung carcinoma SKP2 protein Tissue Chip Immunohistochemistry
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3360145
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148694
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.MCH Hosp Tanggu Dist Tianjin City, Ctr Supersound, Tianjin 300451, Peoples R China
推荐引用方式 GB/T 7714	Zhao Jun,Yang Chunlu,Zhang Huan,et al. Expression of SKP2 protein in lung carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(3):216-221.
APA	Zhao Jun,Yang Chunlu,Zhang Huan,Ding Weizhong,Liu Zhiping,&Liu Jingyi.(2008).Expression of SKP2 protein in lung carcinoma.CHINESE JOURNAL OF CANCER RESEARCH,20(3),216-221.
MLA	Zhao Jun,et al."Expression of SKP2 protein in lung carcinoma".CHINESE JOURNAL OF CANCER RESEARCH 20.3(2008):216-221.