| Hot spots and future directions of research on the neuroprotective effects of nimodipine | |
| Alternative Title | Hot spots and future directions of research on the neuroprotective effects of nimodipine |
| Li Runhui | |
| 2014 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 9Issue:21Pages:1933-1938 |
| Abstract | Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm. |
| Other Abstract | Calcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm. |
| Keyword | ANEURYSMAL SUBARACHNOID HEMORRHAGE FOCAL CEREBRAL-ISCHEMIA DOUBLE-BLIND CEREBROVASCULAR-DISEASE CONTROLLED TRIAL EFFICACY SAFETY MAGNESIUM STROKE BRAIN neuroprotection nerve regeneration nimodipine ischemic cerebrovascular disease Web of Science CiteSpace research fronts development trends scientific mapping visualization |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:5302796 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/148728 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Li Runhui. Hot spots and future directions of research on the neuroprotective effects of nimodipine[J]. NEURAL REGENERATION RESEARCH,2014,9(21):1933-1938. |
| APA | Li Runhui.(2014).Hot spots and future directions of research on the neuroprotective effects of nimodipine.NEURAL REGENERATION RESEARCH,9(21),1933-1938. |
| MLA | Li Runhui."Hot spots and future directions of research on the neuroprotective effects of nimodipine".NEURAL REGENERATION RESEARCH 9.21(2014):1933-1938. |
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