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Hot spots and future directions of research on the neuroprotective effects of nimodipine
Alternative TitleHot spots and future directions of research on the neuroprotective effects of nimodipine
Li Runhui
2014
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume9Issue:21Pages:1933-1938
AbstractCalcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.
Other AbstractCalcium antagonists are widely used in the clinical treatment of ischemic cerebrovascular disease because of their vascular and neuroprotective effects. Nimodipine, a typical calcium antagonist, can cross the blood-brain barrier and act selectively at neurons and blood vessels of target tissues, thus exerting neuroprotective effects. The aim of the present study was to explore the hot spots and future trends of research on the neuroprotective effects of nimodipine. We retrieved 425 articles on the neuroprotective effects of nimodipine that were indexed in the Web of the Science database between 2000 and 2014. The retrieved articles were analyzed using document analysis reporting and the derived information function in the Web of Science, and the information visualization software CiteSpace III. The reference co-citation network was plotted, and the high frequency key words in these publications were used to analyze the research fronts and development trends for nimodipine neuroprotection. According to these co-citation clusters, the research front of nimodipine neuroprotection is the use of randomized controlled trials to study nimodipine intervention of subarachnoid hemorrhage. Using time zone view analysis on hot spots labeled with a key word, the areas of interest in the field of nimodipine neuroprotection are nimodipine pharmacology and therapeutics, blood-brain barrier, trials, and anti-angiospasm.
KeywordANEURYSMAL SUBARACHNOID HEMORRHAGE FOCAL CEREBRAL-ISCHEMIA DOUBLE-BLIND CEREBROVASCULAR-DISEASE CONTROLLED TRIAL EFFICACY SAFETY MAGNESIUM STROKE BRAIN neuroprotection nerve regeneration nimodipine ischemic cerebrovascular disease Web of Science CiteSpace research fronts development trends scientific mapping visualization
Indexed ByCSCD
Language英语
CSCD IDCSCD:5302796
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148728
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Li Runhui. Hot spots and future directions of research on the neuroprotective effects of nimodipine[J]. NEURAL REGENERATION RESEARCH,2014,9(21):1933-1938.
APA Li Runhui.(2014).Hot spots and future directions of research on the neuroprotective effects of nimodipine.NEURAL REGENERATION RESEARCH,9(21),1933-1938.
MLA Li Runhui."Hot spots and future directions of research on the neuroprotective effects of nimodipine".NEURAL REGENERATION RESEARCH 9.21(2014):1933-1938.
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