| Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae | |
| Alternative Title | Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae |
| Zhang JingYi; Zhong HanYu; Shi GuoBing | |
| 2014 | |
| Source Publication | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
 |
| ISSN | 0254-5861 |
| Volume | 33Issue:6Pages:876-880 |
| Abstract | Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2(1)/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) angstrom, beta = 111.9010(10), V= 2072.36(8) angstrom(3), Z = 4, C22H24NO6, M-r = 398.42, D-c, = 1.277 Mg/cm(3), F(000) = 844, lambda(MoK alpha) = 1.54178 angstrom, mu = 0.770 mm(-1), R= 0.0546 and wR = 0.1889 for 3319 observed -reflections (I> 2 sigma(I)). Meanwhile, the compound revealed potential antiproliferative activities in several cancer cells in vitro. |
| Other Abstract | Many small-molecule compounds have been evaluated with potential antiproliferative activities. Ethyl 1-(phenylcarbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, one novel cyclopropylamide analogue of combretastatin-A4 (CA-4), has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P2_1/n, with a = 15.0263(3), b = 7.6574(2), c = 19.4117(4) A, β = 111.9010(10)°, V = 2072.36(8) A~3, Z = 4, C_(22)H_(24)NO_6, Mr = 398.42, D_c = 1.277 Mg/cm~3, F(000) = 844, A(MoKa) = 1.54178 A, μ = 0.770 mm~(-1), R = 0.0546 and wR = 0.1889 for 3319 observed reflections (I > 2σ(I)). Meanwhile, the compound revealed potential antiproliferative activities- in several cancer cells in vitro. |
| Keyword | ANTITUMOR-ACTIVITY DERIVATIVES 3,4,5-trimethoxyphenyl synthesis crystal structure antiproliferative activities |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:5169669 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/148809 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhang JingYi,Zhong HanYu,Shi GuoBing. Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2014,33(6):876-880. |
| APA | Zhang JingYi,Zhong HanYu,&Shi GuoBing.(2014).Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,33(6),876-880. |
| MLA | Zhang JingYi,et al."Synthesis, Crystal Structure and Antiproliferative Activity of Ethyl 1-(Phenylcarbamoyl)-2-3,4,5-trimethoxyphenyl)cyclopropanecarboxylae".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 33.6(2014):876-880. |
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