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Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy
Alternative TitlePredictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy
Li Hua; Lu Ping; Lu Yang; Liu CaiGang; Xu HuiMian; Wang ShuBao; Chen JunQing
2008
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume14Issue:26Pages:4222-4226
AbstractAIM: To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC.
Other AbstractAIM: To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC. METHODS: Data were collected from 85 poorly- differentiated EGC patients who were surgically treated. Association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. RESULTS: Univariate analysis showed that tumor size (OR = 5.814, 95% CI = 1.050 - 32.172, P = 0.044), depth of invasion (OR = 10.763, 95% CI = 1.259 - 92.026, P = 0.030) and lymphatic vessel involvement (OR = 61.697, 95% CI = 2.144 - 175.485, P = 0.007) were the significant and independent risk factors for LNM. The LNM rate was 5.4%, 42.9% and 50%, respectively, in poorly differentiated EGC patients with one, two and three of the risk factors, respectively. No LNM was found in 25 patients without the three risk factors. Forty-four lymph nodes were found to have metastasis, 29 (65.9%) and 15 (34.1%) of the lymph nodes involved were within N1 and beyond N1, respectively, in 12 patients with LNM. CONCLUSION: Endoscopic mucosal resection alone may be sufficient to treat poorly differentiated intramucosal EGC (≤ 2.0 cm in diameter) with no histologically-confirmed lymphatic vessel involvement. When lymphatic vessels are involved, lymph node dissection beyond limited (D1) dissection or DI+ lymph node dissection should be performed depending on the tumor location.
KeywordENDOSCOPIC MUCOSAL RESECTION ELECTROSURGICAL KNIFE RISK-FACTORS INVASION poorly differentiated early gastric cancer lymph node metastasis clinicopathological characteristics endoscopic mucosal resection
Indexed ByCSCD
Language英语
CSCD IDCSCD:3383459
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148831
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Li Hua,Lu Ping,Lu Yang,et al. Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(26):4222-4226.
APA Li Hua.,Lu Ping.,Lu Yang.,Liu CaiGang.,Xu HuiMian.,...&Chen JunQing.(2008).Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy.WORLD JOURNAL OF GASTROENTEROLOGY,14(26),4222-4226.
MLA Li Hua,et al."Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy".WORLD JOURNAL OF GASTROENTEROLOGY 14.26(2008):4222-4226.
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