Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy

IMR OpenIR

	Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy
其他题名	Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy
	Li Hua; Lu Ping; Lu Yang; Liu CaiGang; Xu HuiMian; Wang ShuBao; Chen JunQing
	2008
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
卷号	14 期号:26 页码:4222-4226
摘要	AIM: To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC.
其他摘要	AIM: To identify the predictive clinicopathological factors for lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC) and to further expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of poorly differentiated EGC. METHODS: Data were collected from 85 poorly- differentiated EGC patients who were surgically treated. Association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. RESULTS: Univariate analysis showed that tumor size (OR = 5.814, 95% CI = 1.050 - 32.172, P = 0.044), depth of invasion (OR = 10.763, 95% CI = 1.259 - 92.026, P = 0.030) and lymphatic vessel involvement (OR = 61.697, 95% CI = 2.144 - 175.485, P = 0.007) were the significant and independent risk factors for LNM. The LNM rate was 5.4%, 42.9% and 50%, respectively, in poorly differentiated EGC patients with one, two and three of the risk factors, respectively. No LNM was found in 25 patients without the three risk factors. Forty-four lymph nodes were found to have metastasis, 29 (65.9%) and 15 (34.1%) of the lymph nodes involved were within N1 and beyond N1, respectively, in 12 patients with LNM. CONCLUSION: Endoscopic mucosal resection alone may be sufficient to treat poorly differentiated intramucosal EGC (≤ 2.0 cm in diameter) with no histologically-confirmed lymphatic vessel involvement. When lymphatic vessels are involved, lymph node dissection beyond limited (D1) dissection or DI+ lymph node dissection should be performed depending on the tumor location.
关键词	ENDOSCOPIC MUCOSAL RESECTION ELECTROSURGICAL KNIFE RISK-FACTORS INVASION poorly differentiated early gastric cancer lymph node metastasis clinicopathological characteristics endoscopic mucosal resection
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3383459
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/148831
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Li Hua,Lu Ping,Lu Yang,et al. Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(26):4222-4226.
APA	Li Hua.,Lu Ping.,Lu Yang.,Liu CaiGang.,Xu HuiMian.,...&Chen JunQing.(2008).Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy.WORLD JOURNAL OF GASTROENTEROLOGY,14(26),4222-4226.
MLA	Li Hua,et al."Predictive factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on the surgical strategy".WORLD JOURNAL OF GASTROENTEROLOGY 14.26(2008):4222-4226.