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Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
Alternative TitleGas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
Lei Shuo1; Gao Xun1; Sun Yang2; Yu Xiangyong3; Zhao Longshan1
2018
Source PublicationJournal of Pharmaceutical Analysis
ISSN2095-1779
Volume8Issue:6Pages:373-377
AbstractA simple method was established for the determination of β -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30?m?×?0.32?mm i.d., 0.25?μm) capillary column at the temperature of 80?°C. Electrospray ionization (ESI) was used by selective ion detection at m 42. The temperature for ESI source and inlet was set at 230?°C and 200?°C, respectively. Helium was used as the carrier gas at a flow rate of 25.1?mL
Other AbstractA simple method was established for the determination of β -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30?m?×?0.32?mm i.d., 0.25?μm) capillary column at the temperature of 80?°C. Electrospray ionization (ESI) was used by selective ion detection at m 42. The temperature for ESI source and inlet was set at 230?°C and 200?°C, respectively. Helium was used as the carrier gas at a flow rate of 25.1?mL
KeywordInactivated human rabies vaccine GC-MS Hydrolysis
Indexed ByCSCD
Language英语
CSCD IDCSCD:6379826
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149114
Collection中国科学院金属研究所
Affiliation1.沈阳药科大学
2.Liaoning Medical Device Test Institute
3.中国科学院金属研究所
Recommended Citation
GB/T 7714
Lei Shuo,Gao Xun,Sun Yang,et al. Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis[J]. Journal of Pharmaceutical Analysis,2018,8(6):373-377.
APA Lei Shuo,Gao Xun,Sun Yang,Yu Xiangyong,&Zhao Longshan.(2018).Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis.Journal of Pharmaceutical Analysis,8(6),373-377.
MLA Lei Shuo,et al."Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis".Journal of Pharmaceutical Analysis 8.6(2018):373-377.
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