| Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis | |
| Alternative Title | Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis |
| Lei Shuo1; Gao Xun1; Sun Yang2; Yu Xiangyong3; Zhao Longshan1 | |
| 2018 | |
| Source Publication | Journal of Pharmaceutical Analysis
 |
| ISSN | 2095-1779 |
| Volume | 8Issue:6Pages:373-377 |
| Abstract | A simple method was established for the determination of β -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30?m?×?0.32?mm i.d., 0.25?μm) capillary column at the temperature of 80?°C. Electrospray ionization (ESI) was used by selective ion detection at m 42. The temperature for ESI source and inlet was set at 230?°C and 200?°C, respectively. Helium was used as the carrier gas at a flow rate of 25.1?mL |
| Other Abstract | A simple method was established for the determination of β -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30?m?×?0.32?mm i.d., 0.25?μm) capillary column at the temperature of 80?°C. Electrospray ionization (ESI) was used by selective ion detection at m 42. The temperature for ESI source and inlet was set at 230?°C and 200?°C, respectively. Helium was used as the carrier gas at a flow rate of 25.1?mL |
| Keyword | Inactivated human rabies vaccine GC-MS Hydrolysis |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:6379826 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/149114 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.沈阳药科大学 2.Liaoning Medical Device Test Institute 3.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Lei Shuo,Gao Xun,Sun Yang,et al. Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis[J]. Journal of Pharmaceutical Analysis,2018,8(6):373-377. |
| APA | Lei Shuo,Gao Xun,Sun Yang,Yu Xiangyong,&Zhao Longshan.(2018).Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis.Journal of Pharmaceutical Analysis,8(6),373-377. |
| MLA | Lei Shuo,et al."Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis".Journal of Pharmaceutical Analysis 8.6(2018):373-377. |
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