Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis

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	Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
其他题名	Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis
	Lei Shuo 1; Gao Xun 1; Sun Yang 2; Yu Xiangyong 3; Zhao Longshan 1
	2018
发表期刊	Journal of Pharmaceutical Analysis
ISSN	2095-1779
卷号	8 期号:6 页码:373-377
摘要	A simple method was established for the determination of β -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30?m?×?0.32?mm i.d., 0.25?μm) capillary column at the temperature of 80?°C. Electrospray ionization (ESI) was used by selective ion detection at m 42. The temperature for ESI source and inlet was set at 230?°C and 200?°C, respectively. Helium was used as the carrier gas at a flow rate of 25.1?mL
其他摘要	A simple method was established for the determination of β -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30?m?×?0.32?mm i.d., 0.25?μm) capillary column at the temperature of 80?°C. Electrospray ionization (ESI) was used by selective ion detection at m 42. The temperature for ESI source and inlet was set at 230?°C and 200?°C, respectively. Helium was used as the carrier gas at a flow rate of 25.1?mL
关键词	Inactivated human rabies vaccine GC-MS Hydrolysis
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:6379826
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149114
专题	中国科学院金属研究所
作者单位	1.沈阳药科大学 2.Liaoning Medical Device Test Institute 3.中国科学院金属研究所
推荐引用方式 GB/T 7714	Lei Shuo,Gao Xun,Sun Yang,et al. Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis[J]. Journal of Pharmaceutical Analysis,2018,8(6):373-377.
APA	Lei Shuo,Gao Xun,Sun Yang,Yu Xiangyong,&Zhao Longshan.(2018).Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis.Journal of Pharmaceutical Analysis,8(6),373-377.
MLA	Lei Shuo,et al."Gas chromatography-mass spectrometry method for determination of β-propiolactone in human inactivated rabies vaccine and its hydrolysis analysis".Journal of Pharmaceutical Analysis 8.6(2018):373-377.