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Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection
Alternative TitleLymph node metastasis in early signet ring cell carcinoma: Endoscopic mucosal resection
Li Hua1; Lu Ping1; Zhang Jing2; Xu Huimian1; Wang Shubao1; Chen Junqing1
2008
Source PublicationCHINESE JOURNAL OF CANCER RESEARCH
ISSN1000-9604
Volume20Issue:4Pages:274-278
AbstractObjective: To identify clinicopathological factors predictive of lymph node metastases (LNM) in early signet ring cell carcinoma (SRC), and further to expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of early SRC. Methods: Data from 27 surgically treated patients with early SRC were collected, and the association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Results: In the univariate analysis, a tumor larger than 3.0 cm, submucosal invasion, and the presence of lymphatic vessel involvement (LVI) were significantly associated with a higher rate of LNM (all P<0.05). In the multivariate model, the presence of LVI was found of to be an independent pathological risk factor for LNM. There was no LNM in 14 patients without the three clinicopathological risk factors (a tumor larger than 3.0 cm, submucosal invasion, and the presence of LVI). Conclusion: EMR alone may be sufficient treatment for intramucosal early SRC if the tumor is less than or equal to 3.0 cm in size, and when LVI is absent upon postoperative histological examination. When specimens show LVI, an additional radical gastrectomy with lymphadenectomy should be recommended.
Other AbstractObjective To identify clinicopathological factors predictive of lymph node metastases (LNM) in early signet ring cell carcinoma (SRC), and further to expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of early SRC. Methods Data from 27 surgically treated patients with early SRC were collected, and the association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Results In the univariate analysis, a tumor larger than 3.0 cm, submucosal invasion, and the presence of lymphatic vessel involvement (LVI) were significantly associated with a higher rate of LNM (all P<0.05). In the multivariate model, the presence of LVI was found of to be an independent pathological risk factor for LNM. There was no LNM in 14 patients without the three clinicopathological risk factors (a tumor larger than 3.0 cm, submucosal invasion, and the presence of LVI). Conclusion EMR alone may be sufficient treatment for intramucosal early SRC if the tumor is less than or equal to 3.0 cm in size, and when LVI is absent upon postoperative histological examination. When specimens show LVI, an additional radical gastrectomy with lymphadenectomy should be recommended.
KeywordEARLY GASTRIC-CANCER ELECTROSURGICAL KNIFE Early signet ring cell carcinoma LNM Clinicopathological characteristics Endoscopic mucosal resection
Indexed ByCSCD
Language英语
Funding Project[Nature Science Foundation of Liaoning Province]
CSCD IDCSCD:3427189
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149122
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.华东师范大学
Recommended Citation
GB/T 7714
Li Hua,Lu Ping,Zhang Jing,et al. Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(4):274-278.
APA Li Hua,Lu Ping,Zhang Jing,Xu Huimian,Wang Shubao,&Chen Junqing.(2008).Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection.CHINESE JOURNAL OF CANCER RESEARCH,20(4),274-278.
MLA Li Hua,et al."Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection".CHINESE JOURNAL OF CANCER RESEARCH 20.4(2008):274-278.
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