Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection

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	Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection
其他题名	Lymph node metastasis in early signet ring cell carcinoma: Endoscopic mucosal resection
	Li Hua 1; Lu Ping 1; Zhang Jing 2; Xu Huimian 1; Wang Shubao 1; Chen Junqing 1
	2008
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	20 期号:4 页码:274-278
摘要	Objective: To identify clinicopathological factors predictive of lymph node metastases (LNM) in early signet ring cell carcinoma (SRC), and further to expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of early SRC. Methods: Data from 27 surgically treated patients with early SRC were collected, and the association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Results: In the univariate analysis, a tumor larger than 3.0 cm, submucosal invasion, and the presence of lymphatic vessel involvement (LVI) were significantly associated with a higher rate of LNM (all P<0.05). In the multivariate model, the presence of LVI was found of to be an independent pathological risk factor for LNM. There was no LNM in 14 patients without the three clinicopathological risk factors (a tumor larger than 3.0 cm, submucosal invasion, and the presence of LVI). Conclusion: EMR alone may be sufficient treatment for intramucosal early SRC if the tumor is less than or equal to 3.0 cm in size, and when LVI is absent upon postoperative histological examination. When specimens show LVI, an additional radical gastrectomy with lymphadenectomy should be recommended.
其他摘要	Objective To identify clinicopathological factors predictive of lymph node metastases (LNM) in early signet ring cell carcinoma (SRC), and further to expand the possibility of using endoscopic mucosal resection (EMR) for the treatment of early SRC. Methods Data from 27 surgically treated patients with early SRC were collected, and the association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses. Results In the univariate analysis, a tumor larger than 3.0 cm, submucosal invasion, and the presence of lymphatic vessel involvement (LVI) were significantly associated with a higher rate of LNM (all P<0.05). In the multivariate model, the presence of LVI was found of to be an independent pathological risk factor for LNM. There was no LNM in 14 patients without the three clinicopathological risk factors (a tumor larger than 3.0 cm, submucosal invasion, and the presence of LVI). Conclusion EMR alone may be sufficient treatment for intramucosal early SRC if the tumor is less than or equal to 3.0 cm in size, and when LVI is absent upon postoperative histological examination. When specimens show LVI, an additional radical gastrectomy with lymphadenectomy should be recommended.
关键词	EARLY GASTRIC-CANCER ELECTROSURGICAL KNIFE Early signet ring cell carcinoma LNM Clinicopathological characteristics Endoscopic mucosal resection
收录类别	CSCD
语种	英语
资助项目	[Nature Science Foundation of Liaoning Province]
CSCD记录号	CSCD:3427189
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149122
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.华东师范大学
推荐引用方式 GB/T 7714	Li Hua,Lu Ping,Zhang Jing,et al. Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(4):274-278.
APA	Li Hua,Lu Ping,Zhang Jing,Xu Huimian,Wang Shubao,&Chen Junqing.(2008).Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection.CHINESE JOURNAL OF CANCER RESEARCH,20(4),274-278.
MLA	Li Hua,et al."Lymph Node Metastasis in Early Signet Ring Cell Carcinoma: Endoscopic Mucosal Resection".CHINESE JOURNAL OF CANCER RESEARCH 20.4(2008):274-278.