Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats

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	Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats
其他题名	Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats ☆
	Wang Jun 1; Cui Yan 1; Ge Jing 1; Ma Meijing 2
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:25 页码:1954-1959
摘要	Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinennic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups.
其他摘要	Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg
关键词	UTERINE PERFUSION-PRESSURE ARTERIAL-PRESSURE NITRIC-OXIDE PREGNANCY HOMOCYSTEINE DYSFUNCTION MODEL RISK MICE folic acid preeclampsia hyperhomocysteinemia proteinuria creatinine preeclampsia-like symptom pregnant rats offspring brain nervous system regeneration neural regeneration
收录类别	CSCD
语种	英语
资助项目	[Medical Science and Technology Foundation of Chinese PLA]
CSCD记录号	CSCD:4648164
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149372
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Second Peoples Hosp Tongliao, Department Obstet & Gynaecol, Tongliao 280000, Inner Mongolia, Peoples R China
推荐引用方式 GB/T 7714	Wang Jun,Cui Yan,Ge Jing,et al. Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1954-1959.
APA	Wang Jun,Cui Yan,Ge Jing,&Ma Meijing.(2012).Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats.NEURAL REGENERATION RESEARCH,7(25),1954-1959.
MLA	Wang Jun,et al."Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats".NEURAL REGENERATION RESEARCH 7.25(2012):1954-1959.