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Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats
Alternative TitleFolic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats ☆
Wang Jun1; Cui Yan1; Ge Jing1; Ma Meijing2
2012
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
Volume7Issue:25Pages:1954-1959
AbstractFolic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinennic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia-induced preeclampsia in pregnant rats without influencing brain development of rat pups.
Other AbstractFolic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg
KeywordUTERINE PERFUSION-PRESSURE ARTERIAL-PRESSURE NITRIC-OXIDE PREGNANCY HOMOCYSTEINE DYSFUNCTION MODEL RISK MICE folic acid preeclampsia hyperhomocysteinemia proteinuria creatinine preeclampsia-like symptom pregnant rats offspring brain nervous system regeneration neural regeneration
Indexed ByCSCD
Language英语
Funding Project[Medical Science and Technology Foundation of Chinese PLA]
CSCD IDCSCD:4648164
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149375
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Second Peoples Hosp Tongliao, Department Obstet & Gynaecol, Tongliao 280000, Inner Mongolia, Peoples R China
Recommended Citation
GB/T 7714
Wang Jun,Cui Yan,Ge Jing,et al. Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(25):1954-1959.
APA Wang Jun,Cui Yan,Ge Jing,&Ma Meijing.(2012).Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats.NEURAL REGENERATION RESEARCH,7(25),1954-1959.
MLA Wang Jun,et al."Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats".NEURAL REGENERATION RESEARCH 7.25(2012):1954-1959.
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