| A non-opioid pathway for dynorphin-caused spinal cord injury in rats | |
| Alternative Title | A non-opioid pathway for dynorphin-caused spinal cord injury in rats ☆ |
| Chen Yu; Xiang Liangbi; Liu Jun; Zhou Dapeng; Yu Hailong; Wang Qi; Han Wenfeng; Guo Mingming | |
| 2012 | |
| Source Publication | NEURAL REGENERATION RESEARCH
 |
| ISSN | 1673-5374 |
| Volume | 7Issue:11Pages:815-820 |
| Abstract | Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor. |
| Other Abstract | Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor. |
| Keyword | PROSTATIC ACID-PHOSPHATASE RECEPTOR ANTAGONIST PAIN SENSITIZATION NEURONS MK-801 NMDA INHIBITION TRAUMA spinal cord injury dynorphin kappa opioid receptor antagonist N-methyl-D-aspartate receptor antagonist motor function acid phosphatase |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [Science and Key Technology Research and Development Program of Liaoning Province] |
| CSCD ID | CSCD:4530874 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/149386 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Chen Yu,Xiang Liangbi,Liu Jun,et al. A non-opioid pathway for dynorphin-caused spinal cord injury in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(11):815-820. |
| APA | Chen Yu.,Xiang Liangbi.,Liu Jun.,Zhou Dapeng.,Yu Hailong.,...&Guo Mingming.(2012).A non-opioid pathway for dynorphin-caused spinal cord injury in rats.NEURAL REGENERATION RESEARCH,7(11),815-820. |
| MLA | Chen Yu,et al."A non-opioid pathway for dynorphin-caused spinal cord injury in rats".NEURAL REGENERATION RESEARCH 7.11(2012):815-820. |
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