A non-opioid pathway for dynorphin-caused spinal cord injury in rats

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	A non-opioid pathway for dynorphin-caused spinal cord injury in rats
其他题名	A non-opioid pathway for dynorphin-caused spinal cord injury in rats ☆
	Chen Yu; Xiang Liangbi; Liu Jun; Zhou Dapeng; Yu Hailong; Wang Qi; Han Wenfeng; Guo Mingming
	2012
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	7 期号:11 页码:815-820
摘要	Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.
其他摘要	Intrathecal injection of dynorphin into rats via subarachnoid catheter induces damage to spinal cord tissue and motor function. Injection of the kappa opioid receptor antagonist nor-binaltorphine, or the excitatory amino acid N-methyl-D-aspartate receptor antagonist MK-801 into rats alleviated the pathological changes of dynorphin-caused spinal cord tissue injury and reduced the acid phosphatase activity in the spinal cord. The experimental findings indicate that there are opioid and non-opioid pathways for dynorphin-induced spinal cord injury, and that the non-opioid receptor pathway may be mediated by the excitatory amino acid N-methyl-D-aspartate receptor.
关键词	PROSTATIC ACID-PHOSPHATASE RECEPTOR ANTAGONIST PAIN SENSITIZATION NEURONS MK-801 NMDA INHIBITION TRAUMA spinal cord injury dynorphin kappa opioid receptor antagonist N-methyl-D-aspartate receptor antagonist motor function acid phosphatase
收录类别	CSCD
语种	英语
资助项目	[Science and Key Technology Research and Development Program of Liaoning Province]
CSCD记录号	CSCD:4530874
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149389
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Chen Yu,Xiang Liangbi,Liu Jun,et al. A non-opioid pathway for dynorphin-caused spinal cord injury in rats[J]. NEURAL REGENERATION RESEARCH,2012,7(11):815-820.
APA	Chen Yu.,Xiang Liangbi.,Liu Jun.,Zhou Dapeng.,Yu Hailong.,...&Guo Mingming.(2012).A non-opioid pathway for dynorphin-caused spinal cord injury in rats.NEURAL REGENERATION RESEARCH,7(11),815-820.
MLA	Chen Yu,et al."A non-opioid pathway for dynorphin-caused spinal cord injury in rats".NEURAL REGENERATION RESEARCH 7.11(2012):815-820.