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Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis
Alternative TitleRelationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis
Zhang Shuo; Guo Yang; Ma Yan; Teng Yue
2008
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
ISSN1007-9327
Volume14Issue:8Pages:1286-1292
AbstractAIM: To study the relationship between the cytotoxin-associated gene-A (CagA) status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis.
Other AbstractAIM: To study the relationship between the cytotoxin associated gene-A (CagA) status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis. METHODS: Ten case-control studies, with data on a total of 907 cases and 966 controls, were retrieved and considered; disqualified studies were excluded. The included studies were then tested for heterogeneity, and a meta-analysis was performed. RESULTS: The combined data revealed CagA-bearing strains of H pylori which cause chronic infection are associated with an increased risk of cerebral infarction (OR=2.66,95% CI:2. 17-3.26),but no such relationship was found with CagA-negative strains (OR =0.74,95% CI:0.49-1.10) in the overall population. We performed subgroup analyses, dividing the overall population into European Caucasians and Chinese Hart subgroups, and analyzed the studies according to their subgroup classification. Through the subgroup analysis, an association between cerebral infarction and CagA bearing strains was found in both subgroups (OR=2.60,95% CI:1.93-3.49 in Chinese Han; OR=2.71,95% CI:2.05-3.59 in European Caucasians),but no significant association was found between cerebral infarction and CagA-negative strains (OR=0.81,95% CI:0.45-1.48 in Chinese Han; OR=0.64,95% CI:0.37-1.09 in European Caucasians). CONCLUSION: These results suggest CagA-bearing strains of Hpylori are significantly associated with susceptibility to cerebral infarction in Chinese Han and European Caucasians, but that CagA-negative strains are not a definite predisposing factor in either subgroup. The magnitude of this association with cerebral infarction needs to be confirmed by prospective studies and combined studies of H pylori eradication.
KeywordATHEROSCLEROTIC STROKE CHLAMYDIA-PNEUMONIAE INFECTION INFLAMMATION RISK ANTIBODIES DISEASE EVENTS LINK cytotoxin-associated gene-A H pylori cerebral infarction meta-analysis
Indexed ByCSCD
Language英语
CSCD IDCSCD:3317251
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149419
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhang Shuo,Guo Yang,Ma Yan,et al. Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(8):1286-1292.
APA Zhang Shuo,Guo Yang,Ma Yan,&Teng Yue.(2008).Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis.WORLD JOURNAL OF GASTROENTEROLOGY,14(8),1286-1292.
MLA Zhang Shuo,et al."Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis".WORLD JOURNAL OF GASTROENTEROLOGY 14.8(2008):1286-1292.
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