| Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis | |
| Alternative Title | Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis |
| Zhang Shuo; Guo Yang; Ma Yan; Teng Yue | |
| 2008 | |
| Source Publication | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| ISSN | 1007-9327 |
| Volume | 14Issue:8Pages:1286-1292 |
| Abstract | AIM: To study the relationship between the cytotoxin-associated gene-A (CagA) status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis. |
| Other Abstract | AIM: To study the relationship between the cytotoxin associated gene-A (CagA) status of H pylori strains and cerebral infarction among European Caucasians and Chinese Han by conducting a meta-analysis. METHODS: Ten case-control studies, with data on a total of 907 cases and 966 controls, were retrieved and considered; disqualified studies were excluded. The included studies were then tested for heterogeneity, and a meta-analysis was performed. RESULTS: The combined data revealed CagA-bearing strains of H pylori which cause chronic infection are associated with an increased risk of cerebral infarction (OR=2.66,95% CI:2. 17-3.26),but no such relationship was found with CagA-negative strains (OR =0.74,95% CI:0.49-1.10) in the overall population. We performed subgroup analyses, dividing the overall population into European Caucasians and Chinese Hart subgroups, and analyzed the studies according to their subgroup classification. Through the subgroup analysis, an association between cerebral infarction and CagA bearing strains was found in both subgroups (OR=2.60,95% CI:1.93-3.49 in Chinese Han; OR=2.71,95% CI:2.05-3.59 in European Caucasians),but no significant association was found between cerebral infarction and CagA-negative strains (OR=0.81,95% CI:0.45-1.48 in Chinese Han; OR=0.64,95% CI:0.37-1.09 in European Caucasians). CONCLUSION: These results suggest CagA-bearing strains of Hpylori are significantly associated with susceptibility to cerebral infarction in Chinese Han and European Caucasians, but that CagA-negative strains are not a definite predisposing factor in either subgroup. The magnitude of this association with cerebral infarction needs to be confirmed by prospective studies and combined studies of H pylori eradication. |
| Keyword | ATHEROSCLEROTIC STROKE CHLAMYDIA-PNEUMONIAE INFECTION INFLAMMATION RISK ANTIBODIES DISEASE EVENTS LINK cytotoxin-associated gene-A H pylori cerebral infarction meta-analysis |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3317251 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/149419 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhang Shuo,Guo Yang,Ma Yan,et al. Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(8):1286-1292. |
| APA | Zhang Shuo,Guo Yang,Ma Yan,&Teng Yue.(2008).Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis.WORLD JOURNAL OF GASTROENTEROLOGY,14(8),1286-1292. |
| MLA | Zhang Shuo,et al."Relationship between the cytotoxin-associated gene-A status of H pylori strains and cerebral infarction in European Caucasians and Chinese Han: A meta-analysis".WORLD JOURNAL OF GASTROENTEROLOGY 14.8(2008):1286-1292. |
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