Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury

IMR OpenIR

	Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury
其他题名	Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury
	Li Zhi 1; Zhao Wei 1; Liu Wei 1; Zhou Ye 1; Jia Jingqiao 2; Yang Lifeng 1
	2014
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	9 期号:24 页码:2197-2204
摘要	Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
其他摘要	Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
关键词	AMNIOTIC MEMBRANE REPAIR nerve regeneration stem cells placenta-derived mesenchymal stem cells spinal cord injury neural stem cells nerve-like cells motor function sensory function neural regeneration
收录类别	CSCD
语种	英语
资助项目	[Scientific Research Program of Liaoning Provincial Science and Technology Ministry in China]
CSCD记录号	CSCD:5325092
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149604
专题	中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.Liaoning Prov Wellcare Stem Cells Biotechnology Co L, Benxi, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Li Zhi,Zhao Wei,Liu Wei,et al. Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury[J]. NEURAL REGENERATION RESEARCH,2014,9(24):2197-2204.
APA	Li Zhi,Zhao Wei,Liu Wei,Zhou Ye,Jia Jingqiao,&Yang Lifeng.(2014).Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury.NEURAL REGENERATION RESEARCH,9(24),2197-2204.
MLA	Li Zhi,et al."Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury".NEURAL REGENERATION RESEARCH 9.24(2014):2197-2204.