IMR OpenIR
A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing
Alternative TitleA novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing
Dong Yang; Liu Hong Zhuo; Xu Lu; Li Gang; Ma Zi Ning; Han Fei; Yao Hui Min; Sun Yan Hui; Li San Ming
2010
Source PublicationCHINESE CHEMICAL LETTERS
ISSN1001-8417
Volume21Issue:8Pages:1011-1014
AbstractA membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HCl (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application. (C) 2010 San Ming Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
Other AbstractA membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HC1 (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application
KeywordARTIFICIAL SKIN DESIGN Chitosan Alginate Composite membrane Ciprofloxacin HCl Sustained release Antimicrobial efficacy
Indexed ByCSCD
Language英语
CSCD IDCSCD:3968962
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/149719
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Dong Yang,Liu Hong Zhuo,Xu Lu,et al. A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing[J]. CHINESE CHEMICAL LETTERS,2010,21(8):1011-1014.
APA Dong Yang.,Liu Hong Zhuo.,Xu Lu.,Li Gang.,Ma Zi Ning.,...&Li San Ming.(2010).A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing.CHINESE CHEMICAL LETTERS,21(8),1011-1014.
MLA Dong Yang,et al."A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing".CHINESE CHEMICAL LETTERS 21.8(2010):1011-1014.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dong Yang]'s Articles
[Liu Hong Zhuo]'s Articles
[Xu Lu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dong Yang]'s Articles
[Liu Hong Zhuo]'s Articles
[Xu Lu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dong Yang]'s Articles
[Liu Hong Zhuo]'s Articles
[Xu Lu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.