| A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing | |
| Alternative Title | A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing |
| Dong Yang; Liu Hong Zhuo; Xu Lu; Li Gang; Ma Zi Ning; Han Fei; Yao Hui Min; Sun Yan Hui; Li San Ming | |
| 2010 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 21Issue:8Pages:1011-1014 |
| Abstract | A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HCl (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application. (C) 2010 San Ming Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HC1 (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application |
| Keyword | ARTIFICIAL SKIN DESIGN Chitosan Alginate Composite membrane Ciprofloxacin HCl Sustained release Antimicrobial efficacy |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:3968962 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/149719 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Dong Yang,Liu Hong Zhuo,Xu Lu,et al. A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing[J]. CHINESE CHEMICAL LETTERS,2010,21(8):1011-1014. |
| APA | Dong Yang.,Liu Hong Zhuo.,Xu Lu.,Li Gang.,Ma Zi Ning.,...&Li San Ming.(2010).A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing.CHINESE CHEMICAL LETTERS,21(8),1011-1014. |
| MLA | Dong Yang,et al."A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing".CHINESE CHEMICAL LETTERS 21.8(2010):1011-1014. |
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