A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing

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	A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing
其他题名	A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing
	Dong Yang; Liu Hong Zhuo; Xu Lu; Li Gang; Ma Zi Ning; Han Fei; Yao Hui Min; Sun Yan Hui; Li San Ming
	2010
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	21 期号:8 页码:1011-1014
摘要	A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HCl (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application. (C) 2010 San Ming Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A membrane composed of an alginate (ALG) layer and a chitosan (CHS) layer with sustained antimicrobial efficacy was prepared. Ciprofloxacin HC1 (CIP) was incorporated into the ALG layer. Morphological feature of the composite membrane was analyzed by scanning electron microscopy (SEM). Water uptake capacity, in vitro drug release, and in vitro antimicrobial activity were evaluated. The composite membrane exhibited perfect binding characteristic between the two layers. The water uptake capacity of all the membranes was above 800%. The CIP could release from the composite membranes for 48 h. The membrane could control the bacterial growth persistently. The results suggested that this CHS/ALG composite membrane incorporated with CIP had the potential for wound dressing application
关键词	ARTIFICIAL SKIN DESIGN Chitosan Alginate Composite membrane Ciprofloxacin HCl Sustained release Antimicrobial efficacy
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3968962
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/149719
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Dong Yang,Liu Hong Zhuo,Xu Lu,et al. A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing[J]. CHINESE CHEMICAL LETTERS,2010,21(8):1011-1014.
APA	Dong Yang.,Liu Hong Zhuo.,Xu Lu.,Li Gang.,Ma Zi Ning.,...&Li San Ming.(2010).A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing.CHINESE CHEMICAL LETTERS,21(8),1011-1014.
MLA	Dong Yang,et al."A novel CHS/ALG bi-layer composite membrane with sustained antimicrobial efficacy used as wound dressing".CHINESE CHEMICAL LETTERS 21.8(2010):1011-1014.